Dissymmetric azomethine direct dyes and process for their preparation, cosmetic composition comprising at least one such dye and use thereof

ABSTRACT

The present invention relates to dissymmetric azomethine direct dyes of formula (I) and the leuco forms thereof of formula (II), and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair: 
                         
in which formula (I) or (II) R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , n and n′ are as defined in the description.
 
     The compounds of formula (I) or (II) according to the invention can give powerful, chromatic and sparingly selective colourings with good colour build-up, which are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, light, washing and perspiration.

CROSS REFERENCE TO RELATED APPLICATION

This is a national stage application of PCT/EP2017/082985, filed internationally on Dec. 15, 2017, which claims priority to French Application No. 1662654, filed on Dec. 16, 2016, both of which are incorporated by reference herein in their entireties.

The present invention relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, comprising the application to said keratin fibres of a composition comprising one or more compounds of formula (I) and/or the leuco forms thereof of formula (II), and also to the use of one or more compounds of formula (I) and/or (II) for dyeing keratin fibres, and to a device therefor.

It is known practice to dye keratin fibres, and in particular the hair, with cosmetic compositions containing one or more direct dyes, according to a “direct dyeing” process.

The process conventionally used in direct dyeing consists in applying to keratin fibres one or more direct dyes, or colouring molecules, which have affinity for said fibres, leaving them to stand on the fibres, and then rinsing the fibres. The direct dyes used hitherto are generally nitrobenzene dyes, anthraquinone dyes, nitropyridine dyes, dyes of azo, xanthene, acridine or azine type or triarylmethane-based dyes.

However, the colourings that result therefrom are temporary or semi-permanent, since the nature of the interactions that bind the direct dyes to the keratin fibre and their desorption from the surface and/or the core of the fibre are responsible for their weak dyeing power and their poor fastness with respect to washing, inclement weather or perspiration.

These dyes also have the drawback of lacking in stability towards light, on account of the poor resistance of the chromophore to photochemical attack, which has a tendency to lead to fading over time of the colouring of the keratin fibres.

In addition, although a wide range of colours is currently accessible, it generally proves necessary to combine three dyes of complementary colours—trichromatic principle—in order to obtain a natural chestnut-brown, dark chestnut-brown, brown or black shade (see, for example, WO 95/15144 and WO 95/01772). This tripartite combination does not, however, show good persistence with respect to repeated shampooing. It generally, or even systematically, induces an unaesthetic changing of the colour, which the consumer finds dissuasive.

There is thus a real need for direct dyes that can dye keratin fibres in an intense, chromatic manner with good build-up of the colour, which are stable towards light, and/or capable of giving colourings that are resistant to the various attacking factors to which the fibres may be subjected, such as inclement weather, washing and perspiration.

A particular aim of the present invention is also to be able to dye light keratin fibres efficiently chestnut-brown, dark chestnut-brown, brown or brown with a glint or even black, with a single type of dye of formula (I) or (II) as defined below.

These aims are achieved with the present invention, one subject of which is especially azomethine direct dyes of formula (I) below, organic or mineral acid or base salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof and/or solvates thereof:

in which formula (I):

-   -   n and n′, which may be identical or different, represent an         integer equal to 0, 1, 2, 3, 4 or 5; preferably, n and n′         represent 0 or 1;     -   R₁ and R₂, which may be identical or different, represent:         -   a halogen atom;         -   a sulfonic radical —SO₃H or sulfonate radical —SO₃;         -   a carboxyl radical —CO₂H, a carboxylate radical —COO⁻;         -   an aromatic or non-aromatic, 5- to 10-membered cationic             heterocycle, which is optionally substituted, especially             with one or more identical or different radicals chosen from             C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl;         -   an aromatic or non-aromatic, 5- to 6-membered non-cationic             heterocycle, substituted with:             -   an ammonium radical —N⁺RR′R″, An⁻ with R, R′ and R″,                 which may be identical or different, representing a                 (C₁-C₄)alkyl group optionally substituted with one or                 more hydroxyl groups, such as methyl, ethyl, propyl or                 2-hydroxyethyl, and/or             -   an aromatic or non-aromatic, 5- to 10-membered cationic                 heterocycle, which is optionally substituted, especially                 with one or more identical or different radicals chosen                 from C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl;         -   an ammonium radical —N⁺RR′R″, An⁻, with R, R′ and R″ as             defined previously, and preferably R, R′ and R″, which may             be identical or different, represent a C₁-C₄ alkyl group             such as methyl;         -   amino;         -   hydroxyl, or thiol;         -   a radical —W—R₇, in which:             -   W represents:                 -   an oxygen or sulfur atom,                 -   a divalent group —N(R₈)— or                 -   a linear or branched, saturated or unsaturated,                     preferably saturated, divalent hydrocarbon-based                     chain, comprising from 1 to 14 carbon atoms, said                     hydrocarbon-based chain being:                 -    optionally substituted with one or more radicals,                     which may be identical or different, chosen from the                     following radicals: i) hydroxyl, ii)                     (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″                     with R, R′ and R″ as defined previously, iv)                     aromatic or non-aromatic, optionally substituted, 5-                     to 10-membered cationic heterocycles, preferably a                     5- or 6-membered cationic heteroaryl optionally                     substituted with one or more (C₁-C₄)alkyl groups,                     such as (C₁-C₄)(alkyl)imidazolium, v) aromatic or                     non-aromatic, 5- or 6-membered non-cationic                     heterocycles, substituted with one or more radicals,                     which may be identical or different, chosen from the                     following radicals: a) ammonium —N⁺RR′R″ with R, R′                     and R″ as defined previously, and b), aromatic or                     non-aromatic, 5- to 10-membered cationic                     heterocycle, optionally substituted especially with                     one or more identical or different radicals chosen                     from C₁-C₄ alkyl; preferably, the cationic                     heterocycle is a cationic heteroaryl optionally                     substituted with one or more (C₁-C₄)alkyl groups,                     such as (C₁-C₄)(alkyl)imidazolium;                 -    and/or                 -    optionally interrupted, optionally starting and/or                     optionally terminating with one or more divalent                     heteroatoms or groups, which may be identical or                     different, chosen from:                 -    —O—, —S—, —N(R₁₀)—, —S(O)—, —S(O)₂—, and —C(X)—                     with X representing an oxygen or sulfur atom or a                     group NR₁₀ and R₁₀ representing a hydrogen atom or a                     (C₁-C₆)alkyl group, and                 -    combinations thereof;                 -    preferably optionally interrupted, optionally                     starting and/or optionally terminating with: —O—,                     —N(R₁₀)—, —O—C(O)—, —C(O)—O—, —C(O)—N(H)—,                     —N(H)—C(O)—, —N(H)—C(O)—N(H)—, —O—C(O)—N(H)—,                     —N(H)—C(O)—O—, or —N(H)—C(NH)—NH—;             -   R₇ and R₈, which may be identical or different,                 represent:                 -   a hydrogen atom,                 -   a linear or branched C₁-C₁₄, in particular C₁-C₈ and                     preferably C₁-C₆ alkyl group, said alkyl group                     being:                 -    optionally interrupted with one or more heteroatoms                     or groups, which may be identical or different, such                     as —O—, —S—, —N(R₈)—, —S(O)—, —S(O)₂— and —C(X)—                     with X as defined previously, or combinations                     thereof; and/or                 -    optionally substituted with one or more radicals,                     which may be identical or different, chosen from the                     following radicals: i) hydroxyl, ii)                     (di)(C₁-C₆)(alkylamino, iii) ammoniums —N⁺RR′R″ with                     R, R′ and R″ as defined previously, iv) aromatic or                     non-aromatic, optionally substituted, 5- to                     10-membered cationic heterocycles, preferably a 5-                     or 6-membered cationic heteroaryl optionally                     substituted with one or more (C₁-C₄)alkyl groups,                     such as (C₁-C₄)(alkylimidazolium, v) aromatic or                     non-aromatic, 5- or 6-membered non-cationic                     heterocycles, substituted with one or more radicals,                     which may be identical or different, chosen from the                     following radicals: a) ammonium —N⁺RR′R″ with R, R′                     and R″ as defined previously, and b), aromatic or                     non-aromatic, 5- to 10-membered cationic                     heterocycle, optionally substituted especially with                     one or more identical or different radicals chosen                     from C₁-C₄ alkyl; preferably, the cationic                     heterocycle is a cationic heteroaryl optionally                     substituted with one or more (C₁-C₄)alkyl groups,                     such as (C₁-C₄)(alkylimidazolium;         -   R₃ and R₄, which may be identical or different,             representing:             -   a hydrogen atom,             -   a (C₁-C₆)alkyl radical optionally substituted with one                 or more radicals chosen from i) hydroxyl, ii)                 (C₁-C₄)alkoxy, iii) amino, iv) (C₁-C₆)alkylamino and v)                 di(C₁-C₆)alkylamino;         -   R₅ and R₆, which may be identical or different, represent an             atom or group chosen from:             -   a hydrogen atom,             -   a halogen atom,             -   a C₁-C₆ alkyl radical,             -   a (C₁-C₆)alkyl radical substituted with one or more                 radicals chosen from the following radicals: i)                 hydroxyl, ii) amino —NH₂, iii) (C₁-C₆)alkylamino,                 and iv) di(C₁-C₆)alkylamino,             -   a (C₁-C₆)alkoxy radical, and             -   a (C₁-C₆)alkoxy radical substituted with one or more                 radicals chosen from the following radicals: i)                 hydroxyl, ii) amino, iii) (C₁-C₆)alkylamino, and iv)                 di(C₁-C₆)alkylamino,         -   it being understood that:             -   the compound of formula (I) is dissymmetric,             -   the sum of n+n′ is greater than or equal to 1,             -   when the compound of formula (I) or (II) is cationic, it                 optionally comprises one or more anions An⁻ and                 optionally one or more cations M⁺ to ensure the                 electrical neutrality of the molecule;                 -   with:             -   An⁻ denoting an anion, preferably chosen from bromide,                 chloride, methylsulfate and toluenesulfonate ions or a                 mixture of these ions;             -   M⁺ representing a cation, preferably chosen from sodium,                 potassium, magnesium, calcium and ammonium.

Another subject of the present invention relates to the use of one or more azomethine direct dyes of formula (I), as defined previously, and/or of the leuco forms thereof (II) as defined below, optionally in the presence of one or more chemical oxidizing agents, for dyeing keratin fibres, in particular human keratin fibres such as the hair.

The present invention also relates to a cosmetic composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising one or more azomethine direct dyes of formula (I) as defined previously and/or of the leuco forms thereof (II) as defined below.

In particular, the invention also relates to the use of said cosmetic composition for dyeing keratin fibres, especially human keratin fibres such as the hair.

The invention also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in which the cosmetic composition as defined previously is applied to said fibres, said application optionally being followed by rinsing with water and/or washing, said process being followed by drying naturally or using heating apparatus such as a drying hood or a hairdryer or a hot brush.

The invention relates more particularly to a process for dyeing and lightening keratin fibres, especially human keratin fibres such as the hair, in which (i) said cosmetic composition, free of oxidizing agent, and (ii) a cosmetic composition comprising one or more chemical oxidizing agents are applied to said fibres; compositions (i) and (ii) being applied to said keratin fibres sequentially or simultaneously for a time that is sufficient to obtain the desired lightening, after which the fibres are rinsed, optionally washed with shampoo and rinsed again, and the resulting fibres are dried or left to dry.

The azomethine direct dyes of formula (I) according to the invention can thus give colourings that are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, light, washing and perspiration.

Furthermore, the direct dyes according to the invention can satisfactorily dye keratin fibres, especially producing powerful, chromatic and sparingly selective colourings, and/or colourings with good colour build-up.

The direct dyes according to the invention also have the advantage of being light-stable and can be used in the presence of an oxidizing agent, which facilitates their use in lightening direct dyeing cosmetic compositions based on oxidizing agents.

In other words, the direct dyes according to the present invention lead to persistent colourings and are compatible with cosmetic compositions intended for lightening keratin fibres.

Moreover, a subject of the invention is colourless or weakly coloured compounds of leuco type of formula (II) below, which correspond to the reduced form of the azomethine direct dyes according to the invention of formula (I), organic or mineral acid or base salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof, and/or solvates thereof:

in which formula (II) R₁, R₂, R₃, R₄, R₅, R₆, n and n′ have the same meanings as those indicated previously in formula (I).

The compounds of leuco type according to the invention lead, in the presence of one or more chemical oxidizing agents or following exposure to atmospheric oxygen, to the azomethine direct dyes of formula (I).

It is known practice to use azomethine direct dyes for dyeing keratin fibres, but these dyes are not always satisfactory in terms of the dyeing property.

The novel azomethine direct dyes of formula (I) or the direct dyeing precursors (II) have the feature of being dissymmetric and have the advantage of producing powerful and sparingly chromatic colours. Furthermore, it is possible to obtain natural colours, especially intense brown, dark brown, black or even green colours, on white keratin fibres using a single azomethine direct dye of formula (I) or a single direct dyeing precursor (II), without necessarily having to use a mixture of several direct dyes, or a mixture of several direct dyeing precursors, of complementary colours (trichromatic principle: see, for example, WO 95/15144 and WO 95/01772). The mixture of direct dyes has the drawback of not being stable with respect to light or washing, as a result of which unaesthetic changing of the colour is very often observed. Now, the dyes of the invention show good stability with respect to external agents and also in an oxidizing medium.

Thus, the invention also relates to the use of one or more compounds of leuco type of formula (II) as precursors of the direct dyes of formula (I).

In particular, the invention relates to the use of one or more compounds of leuco type of formula (II) optionally in the presence of one or more chemical oxidizing agents, for dyeing keratin fibres, especially human keratin fibres such as the hair.

The compounds of leuco type of formula (II) used under oxidizing conditions thus have the advantage of giving colourings that are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, washing, light or perspiration.

Moreover, the dyeing process using colourless or weakly coloured compounds of formula (II) followed by a step of revealing the colour in the presence of a chemical oxidizing agent makes it possible to produce “clean” dyeing, i.e. dyeing that produces very little or no staining of clothing or linen such as towels used during said process.

The invention also relates to a multi-compartment device or kit containing a first compartment comprising one or more compounds of formula (I) or of leuco type of formula (II) as defined previously, and a second compartment comprising one or more oxidizing agents.

Other characteristics, aspects, subjects and advantages of the present invention will emerge even more clearly on reading the description and the examples that follow.

For the purposes of the invention, unless otherwise indicated:

-   -   The term “dissymmetric” means that the compounds of formula (I)         or (II) have the feature that, for one and the same compound,         the unit

-   -    cannot be identical to the unit

-   -   The term “anion or anionic counterion” means an anion or a         cosmetically acceptable organic or inorganic anionic group         derived from an organic or mineral acid salt associated with the         cationic charge of the dye; more particularly, the anion is         chosen from: i) halides such as chloride or bromide; ii)         alkylsulfonates, including C₁-C₆ alkylsulfonates: Alk-S(O)₂O⁻         such as methylsulfonate or mesylate and ethylsulfonate; iii)         arylsulfonates: Ar—S(O)₂O⁻ such as benzenesulfonate and         toluenesulfonate or tosylate; iv) citrate; v) succinate; vi)         tartrate; vii) lactate; viii) alkyl sulfates: Alk-O—S(O)O⁻ such         as methyl sulfate and ethyl sulfate; ix) aryl sulfates:         Ar—O—S(O)O⁻ such as benzene sulfate and toluene sulfate; x)         alkoxy sulfates: Alk-O—S(O)₂O⁻ such as methoxy sulfate and         ethoxy sulfate; xi) aryloxy sulfates: Ar—O—S(O)₂O⁻, xii)         phosphates O═P(OH)₂—O⁻, O═P(O⁻)₂—OH O═P(O⁻)₃,         HO—[P(O)(O⁻)]_(w)—P(O)(O⁻)₂ with w being an integer; xiii)         acetate; xiv) triflate; xv) borates such as         tetrafluoroborate, xvi) disulfate S(O)₂O₂ ⁻; xvii) carbonate;         and xviii) hydrogen carbonate;     -   more particularly, the cosmetically acceptable anions are chosen         in particular from halides such as chloride, methosulfates;         alkylsulfonates: Alk-S(O)₂O⁻ such as methylsulfonate or mesylate         and ethylsulfonate; arylsulfonates: Ar—S(O)₂O⁻ such as         benzenesulfonate and toluenesulfonate or tosylate; citrate;         succinate; tartrate; lactate; alkyl sulfates: Alk-O—S(O)O⁻ such         as methyl sulfate; aryl sulfates such as benzene sulfate and         toluene sulfate; phosphate; acetate; triflate; borates such as         tetrafluoroborate; carbonate; and hydrogen carbonate.     -   As the anion, derived from the organic or mineral acid salt,         ensures the electrical neutrality of the molecule, it is         understood that when the anion comprises several anionic         charges, then the same anion may serve for the electrical         neutrality of several cationic groups in the same molecule or         else may serve for the electrical neutrality of several         molecules; for example, a dye of formula (I) or (II) which         contains two cationic groups may contain either two “singly         charged” anionic counterions or one “doubly charged” anionic         counterion such as S(O)₂O₂ ⁻ or O═P(O⁻)₂—OH; and     -   when the compounds of formulae (I) and (II) bear one or more         sulfonate groups SO₃ ⁻ M⁺, it is understood that the compounds         of formulae (I) and (II) can respect the electrical neutrality         by comprising neither M⁺ nor An⁻, the sulfonate group(s) being         “electro-compensated” by the presence of a corresponding amount         of cationic charge via the cationic heterocycle(s) and/or         ammonium radical(s);     -   By way of example: when only R₁ (or, respectively, R₂) of the         compounds of formulae (I) and (II) bears a cationic charge and         when none of the substituents bears an SO₃ ⁻ or CO₂ ⁻ radical,         then the compounds of formula (I) or (II) comprise an anion An⁻         such that the corresponding compound of formula (I) or (II) is         globally neutral (electrical neutrality).     -   When R₁ and R₂ of the compounds of formulae (I) and (II) bear a         cationic charge and when none of the substituents bears an SO₃ ⁻         or CO₂ ⁻ radical, then the compounds of formula (I) comprise two         singly charged anions An⁻ such as two chloride anions or a         doubly charged anion such as a sulfate, such that the         corresponding compound of formula (I) is globally neutral; When         only R₁ (or, respectively, R₂) bears a cationic charge and when         only one of the substituents bears an SO₃ ⁻ or CO₂ ⁻ radical,         then the compounds of formula (I) do not comprise any anions An⁻         such that the corresponding compound of formula (I) is globally         neutral.     -   The term “cation or cationic counterion” means a cosmetically         acceptable organic or inorganic cation or cationic group derived         from an organic or mineral base salt associated with the anionic         charge of the dye; more particularly, the cationic counterion is         chosen from i) alkali metals such as Na⁺ and K⁺, ii)         alkaline-earth metals such as Ca⁺⁺ and Mg⁺⁺, and iii) ammoniums         such as R_(a)R_(b)R_(c)R_(d)N⁺ with R_(a), R_(b), R_(c) and         R_(d), which may be identical or different, representing a         hydrogen atom or a hydroxyl or (C₁-C₈)alkyl group.     -   The term “alkyl” means a saturated, linear or branched,         preferably C₁-C₆ hydrocarbon-based radical;     -   The term “hydroxyalkyl” means an alkyl group as defined         previously substituted with one or more hydroxyl groups,         preferably a (C₁-C₆)alkyl group substituted with a hydroxyl         group, such as hydroxyethyl;     -   The term “(hydroxy)alkyl” means an alkyl or hydroxyalkyl group         as defined previously;     -   The term “alkoxy” means an —O-alkyl group with alkyl as defined         previously; in particular, alkoxy denotes a methoxy or ethoxy         group;     -   The term “cationic heterocycle” means a monocyclic or bicyclic,         preferably monocyclic, 5- to 10-membered, preferably 5- to         8-membered heterocycle, at least one member of which is a         heteroatom bearing a cationic charge such as N⁺, said         heterocycle being saturated or unsaturated, aromatic or         non-aromatic, and also possibly comprising at least one         heteroatom, chosen from oxygen, nitrogen and/or sulfur atoms;     -   The aromatic cationic heterocycles (also known as cationic         heteroaryls) are preferably chosen from imidazoliums,         pyridiniums, pyrimidiniums, benzimidazoliums, benzothiazoliums,         oxazoliums, benzotriazoliums, pyrazoliums, thiazoliums,         triazoliums and benzoxazoliums;     -   The non-aromatic cationic heterocycles are in particular         saturated cationic heterocycles, and are preferably chosen from         piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums;     -   each of said aromatic or non-aromatic, 5- to 10-membered         cationic heterocycles possibly being substituted with one or         more identical or different radicals chosen from         (hydroxy)(C₁-C₄)alkyl radicals;     -   The term “non-cationic heterocycle” means an aromatic or         non-aromatic, 5- to 10-membered, preferably 5- to 6-membered,         uncharged heterocycle, containing at least one heteroatom chosen         from oxygen, nitrogen and/or sulfur atoms, preferably containing         at least one nitrogen atom, and optionally substituted with:         -   a 5- to 10-membered cationic heterocycle as described above,             preferably chosen from i) imidazolium, ii) pyridinium, iii)             piperazinium, iv) pyrrolidinium, v) morpholinium, vi)             pyrimidinium, vii) thiazolium, viii) benzimidazolium, ix)             benzothiazolium, x) oxazolium, benzotriazolium, xi)             pyrazolium, xii) triazolium, xiii) benzoxazolium, xiv)             piperidinium; said cationic heterocycle being optionally             substituted with one or more radicals, which may be             identical or different, chosen from (hydroxy)(C₁-C₄)alkyl             radicals; and/or         -   a C₁-C₄ tri(hydroxy)alkylammonium radical, for instance             trimethylammonium, triethylammonium, dimethylethylammonium,             diethylmethylammonium, diisopropylmethylammonium,             diethylpropylammonium, 2-hydroxyethyldiethylammonium,             β-dihydroxyethylmethylammonium, β-trihydroxyethylammonium,             dimethylhydroxyethylammonium, 2-hydroxyethyldimethylammonium             or 2-hydroxyethylmethylethylammonium.     -   the “aryl” or “heteroaryl” or “heterocyclic” radicals may be         substituted with at least one substituent borne by a carbon         atom, chosen from:         -   a C₁-C₆ alkyl radical optionally substituted with one or             more radicals chosen from the following radicals: hydroxyl,             C₁-C₂ alkoxy, C₂-C₄ (poly)hydroxyalkoxy, acylamino, amino             substituted with two identical or different C₁-C₄ alkyl             radicals optionally bearing at least one hydroxyl group or             the two radicals possibly forming, with the nitrogen atom to             which they are attached, a saturated or unsaturated,             optionally substituted, 5- to 7-membered and preferably 5-             or 6-membered heterocycle optionally comprising another             nitrogen or non-nitrogen heteroatom;         -   a halogen atom;         -   a hydroxyl group;         -   a C₁-C₂ alkoxy radical;         -   a C₂-C₄ (poly)hydroxyalkoxy radical;         -   an amino radical;         -   an amino radical substituted with one or two identical or             different C₁-C₆ alkyl radicals, optionally bearing at least:             -   i) a hydroxyl group,             -   ii) one amino group optionally substituted with one or                 two optionally substituted C₁-C₃ alkyl radicals, said                 alkyl radicals possibly forming with the nitrogen atom                 to which they are attached a saturated or unsaturated,                 optionally substituted 5- to 7-membered heterocycle,                 optionally comprising at least one other nitrogen or                 non-nitrogen heteroatom,             -   iii) a quaternary ammonium group —N⁺R′R″R′″, An⁻ for                 which R′, R″ and R″, which may be identical or                 different, represent a hydrogen atom or a C₁-C₄ alkyl                 group and An⁻ is as defined previously;             -   iv) or an optionally cationic 5- or 6-membered                 heteroaryl radical, preferentially imidazolium,                 optionally substituted with a (C₁-C₄)alkyl radical,                 preferentially methyl;         -   an acylamino radical (—NR—C(O)—R′) in which the radical R is             a hydrogen atom or a C₁-C₄ alkyl radical optionally bearing             at least one hydroxyl group and the radical R′ is a C₁-C₂             alkyl radical;         -   a carbamoyl radical ((R)₂N—C(O)—) in which the radicals R,             which may be identical or different, represent a hydrogen             atom or a C₁-C₄ alkyl radical optionally bearing at least             one hydroxyl group;         -   an alkylsulfonylamino radical (R′—S(O)₂—N(R)—) in which the             radical R represents a hydrogen atom or a C₁-C₄ alkyl             radical optionally bearing at least one hydroxyl group and             the radical R′ represents a C₁-C₄ alkyl radical or a phenyl             radical; an aminosulfonyl radical ((R)₂N—S(O)₂—) in which             the radicals R, which may be identical or different,             represent a hydrogen atom or a C₁-C₄ alkyl radical             optionally bearing at least one hydroxyl group;         -   a carboxylic radical in acid or salified (preferably with an             alkali metal or a substituted or unsubstituted ammonium)             form;         -   a cyano group;         -   a nitro or nitroso group;         -   a polyhaloalkyl group, preferentially trifluoromethyl;     -   the cyclic or heterocyclic part of a non-aromatic radical may be         substituted with at least one substituent chosen from the         following groups:         -   hydroxyl;         -   C₁-C₄ alkoxy or C₂-C₄ (poly)hydroxyalkoxy;         -   C₁-C₄ alkyl;         -   alkylcarbonylamino (R—C(O)—N(R′)—) in which the radical R′             is a hydrogen atom or a C₁-C₄ alkyl radical optionally             bearing at least one hydroxyl group, and the radical R is a             C₁-C₂ alkyl radical or an amino radical optionally             substituted with one or two C₁-C₄ alkyl groups, which may be             identical or different, optionally bearing at least one             hydroxyl group, said alkyl radicals possibly forming, with             the nitrogen atom to which they are attached, a saturated or             unsaturated, optionally substituted 5- to 7-membered             heterocycle optionally comprising at least one other             nitrogen or non-nitrogen heteroatom;         -   alkylcarbonyloxy (R—C(O)—O—) in which the radical R is a             C₁-C₄ alkyl radical or an amino group optionally substituted             with one or two identical or different C₁-C₄ alkyl groups             optionally bearing at least one hydroxyl group, said alkyl             radicals possibly forming with the nitrogen atom to which it             is attached a saturated or unsaturated, optionally             substituted 5- to 7-membered heterocycle, optionally             comprising at least one other nitrogen or non-nitrogen             heteroatom;         -   alkoxycarbonyl (R-G-C(O)—) in which the radical R is a C₁-C₄             alkoxy radical, G is an oxygen atom or an amino group             optionally substituted with a C₁-C₄ alkyl group optionally             bearing at least one hydroxyl group, said alkyl radical             possibly forming with the nitrogen atom to which it is             attached a saturated or unsaturated, optionally substituted             5- to 7-membered heterocycle, optionally comprising at least             one other nitrogen or non-nitrogen heteroatom;         -   a quaternary ammonium group —N+R′R″R′″, An⁻ for which R′, R″             and which may be identical or different, represent a             hydrogen atom or a C₁-C₄ (hydroxy)alkyl group and An⁻ is as             defined previously;     -   a cyclic or heterocyclic radical, or a non-aromatic part of an         aryl or heteroaryl radical, may also be substituted with one or         more oxo groups.

I. Azomethine Direct Dyes

Preferably, the azomethine direct dye(s) of formula (I) used according to the process of the invention are such that, taken together or separately:

-   -   R₁ and R₂, which may be identical or different, represent:         -   a sulfonic radical —SO₃H or sulfonate radical —SO₃;         -   a radical —W′—R′₇, in which:             -   W′ represents an oxygen or sulfur atom or a divalent                 group —N(R′₈)—;             -   R′₇ and R′₈, which may be identical or different,                 represent a linear or branched, saturated or                 unsaturated, preferably saturated, alkyl group,                 comprising from 1 to 8 carbon atoms, said                 hydrocarbon-based chain being:                 -   optionally substituted with one or more radicals,                     which may be identical or different, chosen from the                     following radicals: i) hydroxyl, ii)                     (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″                     with R, R′ and R″ as defined previously, iv)                     aromatic or non-aromatic, optionally substituted, 5-                     to 10-membered cationic heterocycles, preferably a                     5- or 6-membered cationic heteroaryl optionally                     substituted with one or more (C₁-C₄)alkyl groups,                     such as (C₁-C₄)(alkyl)imidazoliums,                     (C₁-C₄)(alkyl)piperaziniums,                     (C₁-C₄)(alkyl)pyrrolidiniums,                     (C₁-C₄)(alkyl)piperidiniums, morpholiniums, v)                     aromatic or non-aromatic, 5- or 6-membered                     non-cationic heterocycles, substituted with a                     radical chosen from the following radicals: a)                     ammonium —N⁺RR′R″, An⁻ with R, R′ and R″ as defined                     previously, and b), aromatic, 5- to 10-membered                     cationic heterocycle, optionally substituted with                     one or more radicals, which may be identical or                     different, chosen from C₁-C₄ alkyl; preferably, the                     cationic heterocycle is a (C₁-C₄)(alkyl)imidazolium;                     and/or                 -   optionally interrupted with one or more divalent                     heteroatoms or groups, which may be identical or                     different, chosen from:                 -    —O—, —N(R₁₀)—, and —C(O)—, with R₁₀ as defined                     previously, and                 -    combinations thereof;                 -    preferably starting and/or terminating and/or                     optionally interrupted with: —O—, —N(R₁₀)—,                     —O—C(O)—, —C(O)—O—, —C(O)—N(H)—, —N(H)—C(O)—,                     —N(H)—C(O)—N(H)—, —O—C(O)—N(H)—, —N(H)—C(O)—O—, or                     —N(H)—C(NH)—NH—;             -   R′₇, and R′₈, which may be identical or different,                 represent:                 -   a hydrogen atom,                 -   a linear or branched C₁-C₁₄, in particular C₁-C₈ and                     preferably C₁-C₆ alkyl group, said alkyl group                     being:                 -    optionally interrupted with one or more heteroatoms                     or groups, which may be identical or different, such                     as —O—, —S—, —N(R₁₀)—, —S(O)—, —S(O)₂— and —C(X)—                     with X and R₁₀ as defined previously, or                     combinations thereof; and/or                 -    optionally substituted with one or more radicals,                     which may be identical or different, chosen from the                     following radicals: i) hydroxyl, ii)                     (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″                     with R, R′ and R″ as defined previously, iv)                     aromatic or non-aromatic, optionally substituted, 5-                     to 10-membered cationic heterocycles, preferably a                     5- or 6-membered cationic heteroaryl optionally                     substituted with one or more (C₁-C₄)alkyl groups,                     such as (C₁-C₄)(alkyl)imidazolium, v) aromatic or                     non-aromatic, 5- or 6-membered non-cationic                     heterocycles, substituted with a radical chosen from                     the following radicals: a) ammonium —N⁺RR′R″ with R,                     R′ and R″ as defined previously, and b), aromatic or                     non-aromatic, 5- to 10-membered cationic                     heterocycle, optionally substituted especially with                     one or more identical or different radicals chosen                     from C₁-C₄ alkyl; preferably, the cationic                     heterocycle is a cationic heteroaryl optionally                     substituted with one or more (C₁-C₄)alkyl groups,                     such as (C₁-C₄)(alkyl)imidazolium;     -   n and n′ represent an integer equal to 0 or 1;     -   R₃ and R₄, which may be identical or different, represent a         hydrogen atom, a (C₁-C₆)alkyl radical, or a (C₁-C₆)alkyl radical         substituted with one or more radicals chosen from hydroxyl         and/or C₁-C₄ alkoxy; preferentially R₃ and R₄ represent a         hydrogen atom;     -   R₅ and R₆ represent a hydrogen atom;     -   An⁻ is an anionic counterion as defined previously, preferably         chosen from bromide, chloride, methyl sulfate and         toluenesulfonate ions or a mixture of these ions; more         preferentially, An⁻ is a halide and even more preferentially a         chloride.         -   More particularly, the azomethine direct dye(s) of             formula (I) used according to the process of the invention             are such that R₁ and R₂, which may be identical or             different, represent a group —W—R₇, in which:             -   W represents an oxygen atom or a divalent group —N(R₈)—;             -   R₇ and R₈ represent:                 -   a hydrogen atom,                 -   a C₁-C₈ alkyl group;                 -    optionally interrupted with one or more heteroatoms                     or groups, which may be identical or different,                     chosen from —O—, —S—, —N(R₁₀)— with R₁₀ as defined                     previously, —S(O)—, S(O)₂, and —C(X)— with X                     representing an oxygen or sulfur atom or N—R₁₀ with                     R₁₀ as defined previously, or combinations thereof                     preferably chosen from: —O—C(O)—, —C(O)—O—,                     —C(O)—N(H)—, —N(H)—C(O)—, —N(H)—C(O)—N(H)—,                     —O—C(O)—N(H)—, —N(H)—C(O)—O—, —N(H)—C(NH)—NH—;                     and/or                 -    optionally substituted with one or more radicals,                     which may be identical or different, chosen from the                     following radicals: i) hydroxyl, ii) C₁-C₄                     alkoxy, iii) amino, iv) C₁-C₄ mono- and/or                     dialkylamino, v) ammoniums —N⁺RR′R″, with R, R′ and                     R″ as defined previously, vi) optionally substituted                     5- to 10-membered cationic heteroaryls or                     heterocycles, preferably a 5- or 6-membered cationic                     heteroaryl or heterocycle, optionally substituted                     with one or more (C₁-C₄)alkyl groups, such as                     imidazoliums, piperaziniums, pyrrolidiniums,                     morpholiniums and piperidiniums, and vii) 5- or                     6-membered non-cationic heteroaryls or heterocycles,                     optionally substituted with a radical chosen from                     ammoniums —N⁺RR′R″ with R, R′ and R″ as defined                     previously, and 5- to 10-membered cationic                     heteroaryls, such as (C₁-C₄)(alkyl)imidazolium;

According to a particular embodiment of the invention, R₁ and R₂, which may be identical or different, represent a group —W—R₇, in which W represents an oxygen atom or a divalent group —N(R₈)—, and R₇ and R₈, which may be identical or different, represent:

-   -   a hydrogen atom,     -   a (C₁-C₈)alkyl group:         -   optionally interrupted with one or more heteroatoms or             groups, which may be identical or different, chosen from             —O—, —S—, —N(H)—, —N(R₁₀)— with R₁₀ as defined previously,             —S(O)—, S(O)₂, and —C(X)— with X representing an oxygen or             sulfur atom or N—R₁₀ with R₁₀ as defined previously, or             combinations thereof preferably chosen from: —O—C(O)—,             —C(O)—O—, —C(O)—N(H)—, —N(H)—C(O)—, —N(H)—C(O)—N(H)—,             —O—C(O)—N(H)—, —N(H)—C(O)—O—, —N(H)—C(NH)—NH—; and/or         -   optionally substituted with one or more radicals, which may             be identical or different, chosen from:             -   hydroxyl radicals;             -   optionally substituted, aromatic or non-aromatic, 5- to                 10-membered cationic heterocycles, preferably an                 aromatic or non-aromatic, 5- or 6-membered cationic                 heterocycle, optionally substituted with one or more                 (C₁-C₄)alkyl groups, such as imidazoliums,                 piperaziniums, pyrrolidiniums, morpholiniums and                 piperidiniums;             -   ammoniums —N⁺RR′R″ with R, R′ and R″ as defined                 previously;             -   aromatic or non-aromatic, 5- or 6-membered non-cationic                 heterocycles, substituted with a radical chosen from                 ammonium radicals —N⁺RR′R″ with R, R′ and R″ as defined                 previously, and/or with an optionally substituted,                 aromatic or non-aromatic, 5- to 10-membered cationic                 heterocycle, preferably a cationic heterocycle                 optionally substituted with one or more (C₁-C₄)alkyl                 groups, such as an imidazolium, a piperazinium, a                 pyrrolidinium, a morpholinium and a piperidinium.

According to a particular embodiment of the invention, the azomethine direct dye(s) of formula (I) used according to the process of the invention are such that R₁ and R₂, which may be identical or different, represent:

-   -   a radical —OR₇;     -   a radical —SR₇;     -   a radical —NR₇R₈;     -   a linear or branched C₁-C₁₄, in particular C₁-C₈ and preferably         C₁-C₆ alkyl radical, said alkyl radical being:         -   optionally interrupted with one or more heteroatoms or             groups, which may be identical or different, chosen from             —O—, —S—, —N(H)—, —N(R₁₀)— with R₁₀ as defined previously,             —S(O)—, S(O)₂, and —C(X)— with X representing an oxygen or             sulfur atom or N—R₁₀ with R₁₀ as defined previously, or             combinations thereof preferably chosen from: —O—C(O)—,             —C(O)—O—, —C(O)—N(H)—, —N(H)—C(O)—, —N(H)—C(O)—N(H)—,             —O—C(O)—N(H)—, —N(H)—C(O)—O—, —N(H)—C(NH)—NH—; and/or         -   optionally substituted with one or more radicals, which may             be identical or different, chosen from the following             radicals: i) hydroxyl, ii) C₁-C₄ alkoxy, iii) amino             —NH₂, iv) C₁-C₆ mono- and/or dialkylamino, v) ammoniums             —N⁺RR′R″ with R, R′ and R″ as defined previously, and vi)             optionally substituted, aromatic or non-aromatic, 5- to             10-membered cationic heterocycles, preferably a 5- or             6-membered cationic heteroaryl optionally substituted with             one or more (C₁-C₄)alkyl groups, such as             (C₁-C₄)(alkyl)imidazolium, vii) aromatic or non-aromatic, 5-             or 6-membered non-cationic heterocycles, substituted with a             radical chosen from the following radicals:             -   ammoniums —N⁺RR′R″ with R, R′ and R″ as defined                 previously, and/or             -   optionally substituted, aromatic or non-aromatic, 5- to                 10-membered cationic heterocycle, preferably a cationic                 heteroaryl optionally substituted with one or more                 (C₁-C₄)alkyl groups, such as (C₁-C₄)(alkyl)imidazolium;             -   a hydroxyl, amino, C₁-C₄ alkylamino, C₁-C₄ dialkylamino,                 C₁-C₄ alkoxy, C₁-C₄ alkyl or C₁-C₄ hydroxyalkyl radical.     -   a linear or branched C₁-C₁₄, in particular C₁-C₈ and preferably         C₁-C₈ alkoxy radical, said alkoxy radical being:         -   optionally interrupted with one or more heteroatoms or             groups, which may be identical or different, chosen from             —O—, —S—, —N(R₁₀)— with R₁₀ as defined previously, —S(O)—,             S(O)₂, and —C(X)— with X representing an oxygen or sulfur             atom or N—R with R as defined previously, or combinations             thereof preferably chosen from: —O—C(O)—, —C(O)—O—,             —C(O)—N(H)—, —N(H)—C(O)—, —N(H)—C(O)—N(H)—, —O—C(O)—N(H)—,             —N(H)—C(O)—O—, —N(H)—C(NH)—NH—; and/or         -   optionally substituted with one or more radicals, which may             be identical or different, chosen from the following             radicals: i) hydroxyl, ii) C₁-C₄ alkoxy, iii) amino             —NH₂, iv) C₁-C₆ mono- and/or dialkylamino, v) ammoniums             —N⁺RR′R″ with R, R′ and R″ as defined previously, and vi)             optionally substituted, aromatic or non-aromatic, 5- to             10-membered cationic heterocycles, preferably a 5- or             6-membered cationic heteroaryl optionally substituted with             one or more (C₁-C₄)alkyl groups, such as             (C₁-C₄)(alkyl)imidazolium, vii) aromatic or non-aromatic, 5-             or 6-membered non-cationic heterocycles, substituted with a             radical chosen from the following radicals:             -   ammoniums —N⁺RR′R″ with R, R′ and R″ as defined                 previously, and/or             -   optionally substituted, aromatic or non-aromatic, 5- to                 10-membered cationic heterocycle, preferably a cationic                 heteroaryl optionally substituted with one or more                 (C₁-C₄)alkyl groups, such as (C₁-C₄)(alkyl)imidazolium;             -   a hydroxyl, amino, C₁-C₄ alkylamino, C₁-C₄ dialkylamino,                 C₁-C₄ alkoxy, C₁-C₄ alkyl or C₁-C₄ hydroxyalkyl radical.

According to a preferred embodiment of the invention, the azomethine direct dye(s) of formula (I) used according to the process of the invention are such that: —W—R₇ represents a group —OR′₇ or —NR′₇R′₈ with R′₇ and R′₈, which may be identical or different, representing:

-   -   a hydrogen atom;     -   a linear or branched C₁-C₁₄ alkyl radical which may be         interrupted with one or more non-adjacent heteroatoms chosen         from oxygen, sulfur and nitrogen atoms, or with one or more         —C(O)—, —O—C(O)—, —NH—C(O)—, —C(O)—NH—, —NH—C(O)—NH—,         —NH—C(O)—O—, —O—C(O)—NH, —N(H)—C(NH)—NH—, —S(O)— or —S(O)₂—         functions, optionally substituted with one or more identical or         different radicals chosen from the following radicals: i)         hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″,         An⁻ with R, R′ and R″ as defined previously, and iv) optionally         substituted, aromatic or non-aromatic, 5- to 10-membered         cationic heterocycles, preferably a 5- or 6-membered cationic         heteroaryl optionally substituted with one or more (C₁-C₄)alkyl         groups, such as (C₁-C₄)(alkyl)imidazolium, v) aromatic or         non-aromatic, 5- or 6-membered non-cationic heterocycles,         substituted with a radical chosen from radicals. Preferably, R₁         and R₂ independently represent a radical —OR′₇ or —NR′₇R′₈ or an         —SO₃H radical.

According to another particularly advantageous embodiment, the azomethine direct dyes according to the invention of formula (I) are such that n and n′ represent an integer equal to 1 and R₁ and R₂ are, respectively, in position 4 and 4′.

According to a particular embodiment, the azomethine direct dyes according to the invention of formula (I) are such that n represents an integer equal to 1, n′ represents an integer equal to 0 and R₁ is in position 4.

Preferably, the ammonium radicals —N⁺RR′R″ described above are chosen from trimethylammonium, triethylammonium, dimethylethylammonium, diethylmethylammonium, diisopropylmethylammonium, diethylpropylammonium, 2-hydroxyethyldiethylammonium, β-dihydroxyethylmethylammonium, β-trihydroxyethylammonium, dimethylhydroxyethylammonium, 2-hydroxyethyldimethylammonium and 2-hydroxyethylmethylethylammonium; preferentially, the ammonium radicals —N⁺RR′R″ are chosen from trimethylammonium and 2-hydroxyethylmethylethylammonium.

According to a particular embodiment of the invention, the cationic heterocycles are 5- to 10-membered and aromatic; preferably chosen from imidazoliums, pyridiniums, pyrimidiniums, benzimidazoliums, benzothiazoliums, oxazoliums, benzotriazoliums, pyrazoliums, thiazoliums, triazoliums and benzoxazoliums; optionally substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(C₁-C₄)alkyl radicals.

According to another embodiment of the invention, the cationic heterocycles are 5- to 10-membered and non-aromatic; preferably chosen from piperaziniums, pyrrolidiniums, morpholiniums, thiazoliums and piperidiniums; each of said non-aromatic 5- to 10-membered cationic heterocycles possibly being substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(C₁-C₄)alkyl radicals.

According to an advantageous variant of the invention, the cationic heterocycles are imidazoliums, which are optionally substituted, especially with one or more identical or different radicals chosen from (hydroxy)(C₁-C₄)alkyl radicals, such as a methyl.

According to another preferential embodiment of the invention, the cationic heterocycles are chosen from imidazoliums, piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums; optionally substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(C₁-C₄)alkyl radicals.

According to a particular embodiment of the invention, the non-cationic heterocycles are 5- or 6-membered; preferably chosen from piperidines, piperazines, pyrrolidines, morpholines, thiazoles, imidazoles and pyridines, more preferentially chosen from piperidines, piperazines, pyrrolidines, morpholines and imidazoles, the 5- or 6-membered non-cationic heterocycles possibly being substituted especially with:

-   -   an ammonium radical —N⁺RR′R″ with R, R′ and R″, which may be         identical or different, representing a (C₁-C₄)alkyl group         optionally substituted with one or more hydroxyl groups, such as         methyl, ethyl, propyl or 2-hydroxyethyl, and/or     -   an aromatic or non-aromatic, 5- to 10-membered cationic         heterocycle, which is optionally substituted, especially with         one or more identical or different radicals chosen from         (hydroxy)(C₁-C₄)alkyl radicals.

According to a particular embodiment of the invention, the non-cationic heterocycles are 5- or 6-membered and non-aromatic, preferably chosen from piperazines, pyrrolidines, morpholines and piperazines, and more preferentially pyrrolidines; said 5- or 6-membered non-cationic heterocycles possibly being substituted especially with:

-   -   an ammonium radical —N⁺RR′R″ with R, R′ and R″, which may be         identical or different, representing a (C₁-C₄)alkyl group         optionally substituted with one or more hydroxyl groups, such as         methyl, ethyl, propyl or 2-hydroxyethyl, and/or     -   an aromatic or non-aromatic, 5- to 10-membered cationic         heterocycle, which is optionally substituted, especially with         one or more identical or different radicals chosen from         (hydroxy)(C₁-C₄)alkyl radicals.

According to another embodiment of the invention, the non-cationic heterocycles are 5- or 6-membered and aromatic, preferably chosen from imidazoles, pyridines, pyrimidines, benzimidazoles, benzothiazoles, oxazoles, benzotriazoles, pyrazoles, thiazoles, triazoles and benzoxazoles; said 5- or 6-membered non-cationic heterocycles possibly being substituted especially with:

-   -   an ammonium radical —N⁺RR′R″ with R, R′ and R″, which may be         identical or different, representing a (C₁-C₄)alkyl group         optionally substituted with one or more hydroxyl groups, such as         methyl, ethyl, propyl or 2-hydroxyethyl, and/or     -   an aromatic or non-aromatic, 5- to 10-membered cationic         heterocycle, which is optionally substituted, especially with         one or more identical or different radicals chosen from         (hydroxy)(C₁-C₄)alkyl radicals.

According to a particular embodiment of the invention, the non-cationic heterocycles contain at least one heteroatom chosen from 0 and N, and are substituted with one or more identical or different C₁-C₄ tri(hydroxy)alkylammonium radicals chosen from trimethylammonium, triethylammonium, dimethylethylammonium, diethylmethylammonium, diisopropylmethylammonium, diethylpropylammonium, 2-hydroxyethyldiethylammonium, β-dihydroxyethylmethylethylammonium, 3-trihydroxyethylammonium, dimethylhydroxyethylammonium, 2-hydroxyethyldimethylammonium and 2-hydroxyethylmethylethylammonium; preferentially, the non-cationic heterocycles contain at least one heteroatom chosen from 0 and N, and are substituted with one or more identical or different C₁-C₄ tri(hydroxy)alkylammonium radicals chosen from trimethylammonium and 2-hydroxyethylmethylethylammonium.

According to an advantageous variant of the invention, the non-cationic heterocycles are pyrrolidines substituted especially with:

-   -   one or more identical or different ammonium radicals —N⁺RR′R″         with R, R′ and R″ as defined previously, preferably a         trimethylammonium radical, and/or     -   an aromatic or non-aromatic, 5- to 10-membered cationic         heterocycle, which is optionally substituted with one or more         (hydroxy)(C₁-C₄)alkyl groups.

According to a particularly advantageous embodiment of the invention, R₁ and R₂, which may be identical or different, represent a group chosen from:

-   -   hydroxyl,     -   amino,     -   —SO₃H,     -   (di)(hydroxy)(C₁-C₆)alkylamino,     -   (hydroxy)(C₁-C₆)alkoxy, in particular C₁-C₆ alkoxy such as         methoxy or ethoxy,     -   (di)(alkoxy)alkylamino.

According to another particularly advantageous embodiment of the invention, R₁ and R₂, which may be identical or different, represent a group chosen from:

-   -   hydroxyl,     -   amino,     -   (di)(hydroxy)(C₁-C₆)alkylamino,     -   (hydroxy)(C₁-C₆)alkoxy, in particular C₁-C₆ alkoxy such as         methoxy or ethoxy,     -   (di)(alkoxy)alkylamino.

The compounds of formula (I) may be used directly for dyeing the hair.

Preferably, the azomethine direct dyes of formula (I) according to the invention are chosen from the following compounds and the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates:

-   -   with An⁻ as defined previously.

Preferably, the direct dyes of formula (I) according to the present invention are of structure (1), (2), (3), (4), (5) or (6) and also the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates.

According to the invention, the compounds of formula (I) may optionally be salified with mineral acids, for instance HCl, HBr, H₂SO₄ or H₃PO₄, or organic acids, for instance acetic acid, lactic acid, tartaric acid, citric acid, succinic acid, benzenesulfonic acid, para-toluenesulfonic acid, formic acid or methanesulfonic acid.

According to the invention, the compounds of formula (I) may also be in the form of solvates, for example a hydrate or a solvate of a linear or branched alcohol, for instance ethanol or isopropanol.

The azomethine direct dyes of formula (I) may be obtained according to the procedure described below:

Another subject of the invention is a process for preparing compounds of formulae (I) and (II) as defined previously, according to the following schemes:

-   -   access to the compounds (I):

-   -   access to the compounds (II):

which consists for the compounds (I):

-   -   a) in a first stage, in reacting one molar equivalent of a         1,5-dinitrobenzene compound (i) comprising in positions 2 and 4         a nucleofugal group Nu with one molar equivalent of aniline         compound (ii); Nu representing a nucleofugal group, such as a         halogen atom, for instance a chlorine atom or a methoxide,         tosylate, mesylate or sulfonate group. Preferably, this reaction         is performed i) in a polar protic solvent such as in water or a         mixture of water/C₁-C₁₀ alcohol such as ethanol or in a polar         aprotic solvent such as in 1-methyl-2-pyrrolidinone, acetone,         acetonitrile, pyridine or N,N-dimethylformamide, ii) and/or in         the presence of one or more mineral or organic basifying agents,         as defined below, chosen in particular from         diisopropylethylamine, trimethylamine, sodium hydroxide,         potassium hydroxide, a mineral carbonate such as potassium         carbonate, or an acetate, iii) and/or at a temperature of         between 0° C. and 75° C., preferably at 75° C.; and then     -   b) in a second stage, in maintaining the reaction medium under         stirring for a time of between 5 minutes and 48 hours, more         particularly between 30 minutes and 24 hours if the reaction is         performed at room temperature; and then     -   c) the reaction product (iii) is optionally purified via a         standard technique such as recrystallization, filtration or         chromatography;     -   d) in a third stage, in reacting compound (iii) with one molar         equivalent of aniline compound (iv); preferably, this reaction         is performed i) in a polar protic solvent such as in water or a         mixture of water/C₁-C₁₀ alcohol such as ethanol or in a polar         aprotic solvent such as in 1-methyl-2-pyrrolidinone, acetone,         acetonitrile, pyridine or N,N-dimethylformamide, ii) and/or in         the presence of one or more mineral or organic basifying agents,         as defined below, chosen in particular from         diisopropylethylamine, trimethylamine, sodium hydroxide,         potassium hydroxide, a mineral carbonate such as potassium         carbonate, or an acetate, iii) and/or at a temperature of         between room temperature, i.e. 25° C., and the reflux         temperature the solvent, preferably at room temperature; and         then     -   e) in a fourth stage, in maintaining the reaction medium under         stirring for a time of between 5 minutes and 48 hours, more         particularly between 30 minutes and 24 hours; and then     -   f) the reaction product (v) is optionally purified via a         standard technique such as recrystallization, filtration or         chromatography;     -   g) according to another variant, compound (iii) is not purified,         and reacts with one molar equivalent of aniline compound (iv)         under the same conditions as steps d) and e), to give the         product (v), which is optionally purified via a standard         technique such as recrystallization, filtration or         chromatography;     -   h) in a fifth stage, in performing a reduction reaction on         compound (v). Preferably, the reduction of compound (v) may be         performed in the presence of hydrazine, of ammonium formate, or         under a hydrogen atmosphere, and in the presence of a         hydrogenation catalyst based especially on a metal, for example         palladium, nickel or rhodium, the reduction preferentially being         performed with palladium on charcoal (Pd/C) under a hydrogen         atmosphere. Preferentially, this reaction is performed in a         solvent such as esters, in particular such as (C₁-C₆)alkyl         acetates, in particular ethyl acetate, (C₁-C₆)alkanols (i.e. a         compound of formula R—OH with R═(C₁-C₆)-alkyl) such as ethanol         or methanol, and mixtures thereof; better still, the solvent is         ethanol, methanol or a mixture of the two; to give compound         (I′). Compound (I′) is a particular compound of formula (I)         according to the invention, in which R₃ and R₄ represent a         hydrogen atom.         -   The conditions under which the reduction may be performed,             such as the temperature, the amount of metal, the hydrogen             pressure, the reaction time and the concentration, may be             determined by a person skilled in the art.         -   Advantageously, the reduction is performed at a temperature             of between 20 and 25° C. in the presence of a catalytic             amount of the hydrogenation catalyst, better still based on             palladium such as Pd/C, and at a hydrogen pressure of             greater than or equal to 1 bar, especially between 1 and 5             bar. The amount of catalyst is advantageously less than 10             mol % relative to the molar amount of the compound of             formula (v) to be hydrogenated;     -   i) compound (1′) possibly being N-substituted with halogenated         reagents R₃-Hal and R₄-Hal with Hal representing a halogen atom,         preferably Cl or I, preferably with heating at the reflux point         of the solvent and in the presence of an alkaline agent, in         particular in a polar aprotic solvent such as THF, to give         compound (I) according to the invention after filtration,         removal of the precipitate and optionally purification by         chromatography or recrystallization;         it being understood that in the formulae (i), (ii), (iii),         (iv), (v) and (I), the radicals R₁ to R₁₀, n and n′ are as         defined previously.

Said process consists for the compounds (II) in performing a reduction reaction on the compounds (I); synthetic approaches similar to this scheme are described in patent applications FR2056799, FR2047932, FR2165965 and FR2262023.

The conditions under which the reduction may be performed on (v), such as the temperature, the amount of metal, the hydrogen pressure, the reaction time and the concentration, may be determined by a person skilled in the art.

Advantageously, the reduction is performed at a temperature of between 20 and 25° C. in the presence of a catalytic amount of the hydrogenation catalyst, advantageously based on palladium such as Pd/C, and at a hydrogen pressure of greater than or equal to 1 bar, especially between 1 and 5 bar. The amount of catalyst is advantageously less than 10 mol % relative to the molar amount of the compound of formula (v) to be hydrogenated.

The compounds of formula (i) are commercial compounds that are well known to those skilled in the art, such as 1,3-dichloro-4,6-dinitrobenzene (#CAS=3698-83-7) sold by Sigma-Aldrich under the reference 513237.

The characterization is performed by NMR spectroscopy and/or mass spectrometry.

II. Cosmetic Composition

The present invention also relates to a cosmetic composition, in particular for dyeing keratin fibres, more particularly human keratin fibres such as the hair, comprising one or more direct dyes of formula (I) as defined previously.

Preferably, the cosmetic composition comprises one or more azomethine direct dyes of formula (I) according to the invention chosen from compounds (1) to (16) as defined previously, the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates, and also mixtures thereof.

Even more preferentially, the cosmetic composition comprises one or more azomethine direct dyes of formula (I) chosen from compounds (1), (2), (3), (4), (5) and (6).

According to a particular embodiment, the cosmetic composition according to the invention also comprises one or more chemical oxidizing agents, chosen in particular from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, peracids, and oxidase enzymes (with the possible cofactors thereof), among which mention may be made of peroxidases, 2-electron oxidoreductases such as uricases, and 4-electron oxygenases, for instance laccases, and preferably, the chemical oxidizing agent is hydrogen peroxide.

The direct dye(s) as defined previously may be present in the cosmetic composition according to the invention in a content ranging from 0.001% to 10% by weight, preferably in a content ranging from 0.005% to 6% by weight and preferentially in a content ranging from 0.1% to 1% relative to the total weight of the cosmetic composition.

The cosmetic composition according to the invention may also comprise one or more additional dyes chosen from oxidation dyes.

The oxidation dyes are generally chosen from one or more oxidation bases optionally combined with one or more couplers.

By way of example, the oxidation bases are chosen from para-phenylenediamines, bis(phenyl)alkylenediamines, para-aminophenols, ortho-aminophenols and heterocyclic bases, and the corresponding addition salts.

Among the para-phenylenediamines that may be mentioned are, for example, para-phenylenediamine, para-toluenediamine, 2-chloro-para-phenylenediamine, 2,3-dimethyl-para-phenylenediamine, 2,6-dimethyl-para-phenylenediamine, 2,6-diethyl-para-phenylenediamine, 2,5-dimethyl-para-phenylenediamine, N,N-dimethyl-para-phenylenediamine, N,N-diethyl-para-phenylenediamine, N,N-dipropyl-para-phenylenediamine, 4-amino-N,N-diethyl-3-methylaniline, N,N-bis(β-hydroxyethyl)-para-phenylenediamine, 4-N,N-bis(β-hydroxyethyhamino-2-methylaniline, 4-N,N-bis(β-hydroxyethyl)amino-2-chloroaniline, 2-β-hydroxyethyl-para-phenylenediamine, 2-methoxymethyl-para-phenylenediamine, 2-fluoro-para-phenylenediamine, 2-isopropyl-para-phenylenediamine, N-(β-hydroxypropyl)-para-phenylenediamine, 2-hydroxymethyl-para-phenylenediamine, N,N-dimethyl-3-methyl-para-phenylenediamine, N-ethyl-N-(β-hydroxyethyl)-para-phenylenediamine, N-(β,γ-dihydroxypropyl)-para-phenylenediamine, N-(4′-aminophenyl)-para-phenylenediamine, N-phenyl-para-phenylenediamine, 2-β-hydroxyethyloxy-para-phenylenediamine, 2-β-acetylaminoethyloxy-para-phenylenediamine, N-(β-methoxyethyl)-para-phenylenediamine, 4-aminophenylpyrrolidine, 2-thienyl-para-phenylenediamine, 2-β-hydroxyethylamino-5-aminotoluene and 3-hydroxy-1-(4′-aminophenyl)pyrrolidine, and the corresponding addition salts with an acid.

Among the para-phenylenediamines mentioned above, para-phenylenediamine, para-toluenediamine, 2-isopropyl-para-phenylenediamine, 2-β-hydroxyethyl-para-phenylenediamine, 2-β-hydroxyethyloxy-para-phenylenediamine, 2,6-dimethyl-para-phenylenediamine, 2,6-diethyl-para-phenylenediamine, 2,3-dimethyl-para-phenylenediamine, N,N-bis(β-hydroxyethyl)-para-phenylenediamine, 2-chloro-para-phenylenediamine and 2-β-acetylaminoethyloxy-para-phenylenediamine, and the corresponding addition salts with an acid, are particularly preferred.

Among the bis(phenyl)alkylenediamines that may be mentioned, for example, are N,N′-bis(β-hydroxyethyl)-N,N′-bis(4′-aminophenyl)-1,3-diaminopropanol, N,N′-bis(β-hydroxyethyl)-N,N′-bis(4′-aminophenyl)ethylenediamine, N,N′-bis(4-aminophenyl)tetramethylenediamine, N,N′-bis(β-hydroxyethyl)-N,N′-bis(4-aminophenyl)tetramethylenediamine, N,N′-bis(4-methylaminophenyl)tetramethylenediamine, N,N′-bis(ethyl)-N,N′-bis(4′-amino-3′-methylphenyl)ethylenediamine and 1,8-bis(2,5-diaminophenoxy)-3,6-dioxaoctane, and the corresponding addition salts.

Among the para-aminophenols that are mentioned are, for example, para-aminophenol, 4-amino-3-methylphenol, 4-amino-3-fluorophenol, 4-amino-3-chlorophenol, 4-amino-3-hydroxymethylphenol, 4-amino-2-methylphenol, 4-amino-2-hydroxymethylphenol, 4-amino-2-methoxymethylphenol, 4-amino-2-aminomethylphenol, 4-amino-2-(β-hydroxyethyl-aminomethyl)phenol and 4-amino-2-fluorophenol, and the corresponding addition salts with an acid.

Among the ortho-aminophenols that may be mentioned, for example, are 2-aminophenol, 2-amino-5-methylphenol, 2-amino-6-methylphenol and 5-acetamido-2-aminophenol, and the corresponding addition salts.

Among the heterocyclic bases that may be mentioned, for example, are pyridine, pyrimidine and pyrazole derivatives.

Among the pyridine derivatives that may be mentioned are the compounds described, for example, in patents GB 1 026 978 and GB 1 153 196, for example 2,5-diaminopyridine, 2-(4-methoxyphenyl)amino-3-aminopyridine and 3,4-diaminopyridine, and the corresponding addition salts.

Other pyridine oxidation bases that are useful in the present invention are the 3-aminopyrazolo[1,5-a]pyridine oxidation bases or the corresponding addition salts described, for example, in patent application FR 2 801 308. Examples that may be mentioned include pyrazolo[1,5-a]pyrid-3-ylamine, 2-acetylaminopyrazolo[1,5-a]pyrid-3-ylamine, 2-(morpholin-4-yl)pyrazolo[1,5-a]pyrid-3-ylamine, 3-aminopyrazolo[1,5-a]pyridine-2-carboxylic acid, 2-methoxypyrazolo[1,5-a]pyrid-3-ylamine, (3-aminopyrazolo[1,5-a]pyrid-7-yl)methanol, 2-(3-aminopyrazolo[1,5-a]pyrid-5-yl)ethanol, 2-(3-aminopyrazolo[1,5-a]pyrid-7-yl)ethanol, (3-aminopyrazolo[1,5-a]pyrid-2-yl)methanol, 3,6-diaminopyrazolo[1,5-a]pyridine, 3,4-diaminopyrazolo[1,5-a]pyridine, pyrazolo[1,5-a]pyridine-3,7-diamine, 7-(morpholin-4-yl)pyrazolo[1,5-a]pyrid-3-ylamine, pyrazolo[1,5-a]pyridine-3,5-diamine, 5-(morpholin-4-yl)pyrazolo[1,5-a]pyrid-3-ylamine, 2-[(3-aminopyrazolo[1,5-a]pyrid-5-yl)(2-hydroxyethyl)amino]ethanol, 2-[(3-aminopyrazolo[1,5-a]pyrid-7-yl)(2-hydroxyethyl)amino]ethanol, 3-aminopyrazolo[1,5-a]pyridin-5-ol, 3-aminopyrazolo[1,5-a]pyridin-4-ol, 3-aminopyrazolo[1,5-a]pyridin-6-ol, 3-aminopyrazolo[1,5-a]pyridin-7-ol, 2-β-hydroxyethoxy-3-aminopyrazolo[1,5-a]pyridine and 2-(4-dimethylpiperazinium-1-yl)-3-aminopyrazolo[1,5-a]pyridine, and the corresponding addition salts.

More particularly, the oxidation bases that are useful in the present invention are chosen from 3-aminopyrazolo[1,5-a]pyridines and are preferably substituted on carbon atom 2 with:

a) a (di)(C₁-C₆)(alkyl)amino group, said alkyl group possibly being substituted with at least one hydroxyl, amino or imidazolium group;

b) an optionally cationic 5- to 7-membered heterocycloalkyl group comprising from 1 to 3 heteroatoms, optionally substituted with one or more (C₁-C₆)alkyl groups such as a di(C₁-C₄)alkylpiperazinium group; or

c) a (C₁-C₆)alkoxy group optionally substituted with one or more hydroxyl groups, such as a β-hydroxyaIkoxy group, and the corresponding addition salts.

Among the pyrimidine derivatives that may be mentioned are the compounds described, for example, in patents DE 2359399; JP 88-169571; JP 05-63124; EP 0770375 or patent application WO 96/15765, such as 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6-triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopyrimidine, 2,5,6-triaminopyrimidine and the addition salts thereof and the tautomeric forms thereof, when a tautomeric equilibrium exists.

Among the pyrazole derivatives that may be mentioned are the compounds described in patents DE 3843892 and DE 4133957 and patent applications WO 94/08969, WO 94/08970, FR-A-2 733 749 and DE 195 43 988, for instance 4,5-diamino-1-methylpyrazole, 4,5-diamino-1-(β-hydroxyethyl)pyrazole, 3,4-diaminopyrazole, 4,5-diamino-1-(4′-chlorobenzyl)pyrazole, 4,5-diamino-1,3-dimethylpyrazole, 4,5-diamino-3-methyl-1-phenylpyrazole, 4,5-diamino-1-methyl-3-phenylpyrazole, 4-amino-1,3-dimethyl-5-hydrazinopyrazole, 1-benzyl-4,5-diamino-3-methylpyrazole, 4,5-diamino-3-tert-butyl-1-methylpyrazole, 4,5-diamino-1-tert-butyl-3-methylpyrazole, 4,5-diamino-1-(β-hydroxyethyl)-3-methylpyrazole, 4,5-diamino-1-ethyl-3-methylpyrazole, 4,5-diamino-1-ethyl-3-(4′-methoxyphenyl)pyrazole, 4,5-diamino-1-ethyl-3-hydroxymethylpyrazole, 4,5-diamino-3-hydroxymethyl-1-methylpyrazole, 4,5-diamino-3-hydroxymethyl-1-isopropylpyrazole, 4,5-diamino-3-methyl-1-isopropylpyrazole, 4-amino-5-(2′-aminoethyl)amino-1,3-dimethylpyrazole, 3,4,5-triaminopyrazole, 1-methyl-3,4,5-triaminopyrazole, 3,5-diamino-1-methyl-4-methylaminopyrazole and 3,5-diamino-4-(β-hydroxyethyl)amino-1-methylpyrazole, and the corresponding addition salts. Use may also be made of 4,5-diamino-1-(β-methoxyethyl)pyrazole.

A 4,5-diaminopyrazole will preferably be used and even more preferentially 4,5-diamino-1-(β-hydroxyethyl)pyrazole and/or a corresponding salt.

The pyrazole derivatives that may also be mentioned include diamino-N,N-dihydropyrazolopyrazolones and in particular those described in patent application FR-A-2 886 136, such as the following compounds and the corresponding addition salts: 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-ethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-isopropylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-(pyrrolidin-1-yl)-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 4,5-diamino-1,2-dimethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-diethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-bis(2-hydroxyethyl)-1,2-dihydropyrazol-3-one, 2-amino-3-(2-hydroxyethyhamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-dimethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2,3-diamino-5,6,7,8-tetrahydro-1H,6H-pyridazino[1,2-a]pyrazol-1-one, 4-amino-1,2-diethyl-5-(pyrrolidin-1-yl)-1,2-dihydropyrazol-3-one, 4-amino-5-(3-dimethylaminopyrrolidin-1-yl)-1,2-diethyl-1,2-dihydropyrazol-3-one and 2,3-diamino-6-hydroxy-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one.

Use will preferably be made of 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one and/or a corresponding salt.

Heterocyclic bases that will preferably be used are 4,5-diamino-1-(β-hydroxyethyl)pyrazole and/or 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one and/or a corresponding salt.

The composition according to the invention may optionally comprise one or more coupling agents advantageously chosen from those conventionally used in the dyeing of keratin fibres.

Among these coupling agents, mention may be made in particular of meta-phenylenediamines, meta-aminophenols, meta-diphenols, naphthalene-based coupling agents and heterocyclic coupling agents, and also the corresponding addition salts.

Mention may be made, for example, of 1,3-dihydroxybenzene, 1,3-dihydroxy-2-methylbenzene, 4-chloro-1,3-dihydroxybenzene, 2,4-diamino-1-(β-hydroxyethyloxy)benzene, 2-amino-4-(β-hydroxyethylamino)-1-methoxybenzene, 1,3-diaminobenzene, 1,3-bis(2,4-diaminophenoxy)propane, 3-ureidoaniline, 3-ureido-1-dimethylaminobenzene, sesamol, 1-β-hydroxyethylamino-3,4-methylenedioxybenzene, α-naphthol, 2-methyl-1-naphthol, 6-hydroxyindole, 4-hydroxyindole, 4-hydroxy-N-methylindole, 2-amino-3-hydroxypyridine, 6-hydroxybenzomorpholine, 3,5-diamino-2,6-dimethoxypyridine, 1-N-(β-hydroxyethyl)amino-3,4-methylenedioxybenzene, 2,6-bis(β-hydroxyethylamino)toluene, 6-hydroxyindoline, 2,6-dihydroxy-4-methylpyridine, 1-H-3-methylpyrazol-5-one, 1-phenyl-3-methylpyrazol-5-one, 2,6-dimethylpyrazolo[1,5-b]-1,2,4-triazole, 2,6-dimethyl[3,2-c]-1,2,4-triazole and 6-methylpyrazolo[1,5-a]benzimidazole, 2-methyl-5-aminophenol, 5-N-(β-hydroxyethyl)amino-2-methylphenol, 3-aminophenol and 3-amino-2-chloro-6-methylphenol, the corresponding addition salts with an acid and the corresponding mixtures.

In general, the addition salts of oxidation bases and couplers that may be used in the context of the invention are chosen in particular from the addition salts with an acid such as the hydrochlorides, hydrobromides, sulfates, citrates, succinates, tartrates, lactates, tosylates, benzenesulfonates, phosphates and acetates.

The oxidation base(s) each advantageously represent from 0.001% to 10% by weight relative to the total weight of the composition, and preferably from 0.005% to 5% by weight relative to the total weight of the composition and of the ready-to-use composition.

The coupler(s), if it (they) are present, each advantageously represent from 0.001% to 10% by weight relative to the total weight of the composition, and preferably from 0.005% to 5% by weight relative to the total weight of the composition and of the ready-to-use composition.

The composition according to the invention may optionally comprise b) one or more synthetic or natural direct dyes chosen from cationic, anionic and nonionic species, preferably cationic and nonionic species, either as sole dyes or in addition to the additional oxidation dye(s).

Examples of suitable direct dyes that may be mentioned include azo direct dyes; (poly)methine dyes such as cyanines, hemicyanines and styryls; carbonyl dyes; azine dyes; nitro(hetero)aryl dyes; tri(hetero)arylmethane dyes; porphyrin dyes; phthalocyanine dyes and natural direct dyes, alone or in the form of mixtures.

The direct dyes are preferably cationic direct dyes. Mention may be made of the hydrazono cationic dyes of formulae (IIIa) and (III′a), the azo cationic dyes (IVa) and (IV′a) and the diazo cationic dyes (Va) below:

in which formulae (IIIa), (III′a), (IVa), (IV′a) and (Va):

-   -   Het⁺ represents a cationic heteroaryl radical, preferably         bearing an endocyclic cationic charge, such as imidazolium,         indolium or pyridinium, optionally substituted preferably with         one or more (C₁-C₈)alkyl groups such as methyl;     -   Ar⁺ represents an aryl radical, such as phenyl or naphthyl,         bearing an exocyclic cationic charge, preferably ammonium,         particularly tri(C₁-C₈)alkylammonium such as trimethylammonium;     -   Ar represents an aryl group, in particular phenyl, which is         optionally substituted, preferably with one or more         electron-donating groups such as i) optionally substituted         (C₁-C₈)alkyl, ii) optionally substituted (C₁-C₈)alkoxy, iii)         (di)(C₁-C₈)(alkyl)amino optionally substituted on the alkyl         group(s) with a hydroxyl group, iv) aryl(C₁-C₈)alkylamino, v)         optionally substituted N—(C₁-C₈)alkyl-N-aryl(C₁-C₈)alkylamino         or, as a variant, Ar represents a julolidine group;     -   Ar′ represents an optionally substituted divalent         (hetero)arylene group such as phenylene, particularly         para-phenylene, or naphthalene, which is optionally substituted,         preferably with one or more (C₁-C₈)alkyl, hydroxyl or         (C₁-C₈)alkoxy groups;     -   Ar″ represents an optionally substituted (hetero)aryl group such         as phenyl or pyrazolyl, which are optionally substituted,         preferably with one or more (C₁-C₈)alkyl, hydroxyl,         (di)(C₁-C₈)(alkyl)amino, (C₁-C₈)alkoxy or phenyl groups;     -   R^(a) and R^(b), which may be identical or different, represent         a hydrogen atom or a (C₁-C₈)alkyl group, which is optionally         substituted, preferably with a hydroxyl group;

or, as a variant, the substituent R^(a) with a substituent of Het⁺ and/or R^(b) with a substituent of Ar and/or R^(a) with R^(b) form, together with the atoms that bear them, a (hetero)cycloalkyl; in particular, R^(a) and R^(b) represent a hydrogen atom or a (C₁-C₄)alkyl group, which is optionally substituted with a hydroxyl group;

-   -   An⁻ represents an anionic counterion, such as mesylate or         halide.

Mention may be made in particular of azo and hydrazono cationic dyes bearing an endocyclic cationic charge of formulae (IIIa), (III′a) and (IVa) as defined previously. More particularly, those of formulae (IIIa), (III′a) and (IVa) derived from the dyes described in patent applications WO 95/15144, WO 95/01772 and EP-714954.

Preferably, the cationic part is derived from the following derivatives:

formulae (IIIa-1) and (IVa-1) with:

-   -   R¹ representing a (C₁-C₄)alkyl group such as methyl;     -   R² and R³, which may be identical or different, representing a         hydrogen atom or a (C₁-C₄)alkyl group, such as methyl; and     -   R⁴ representing a hydrogen atom or an electron-donating group         such as an optionally substituted (C₁-C₈)alkyl group, an         optionally substituted (C₁-C₈)alkoxy group, or a         (di)(C₁-C₈)(alkyl)amino group optionally substituted on the         alkyl group(s) with a hydroxyl group; in particular, R⁴         represents a hydrogen atom,     -   Z represents a CH group or a nitrogen atom, preferably CH,     -   An⁻ represents an anionic counterion, such as mesylate or         halide.

In particular, the dye of formulae (IIIa-1) and (IVa-1) is chosen from Basic Red 51, Basic Yellow 87 and Basic Orange 31 or corresponding derivatives:

Among the natural direct dyes that may be used according to the invention, mention may be made of hennotannic acid, juglone, alizarin, purpurin, carminic acid, kermesic acid, purpurogallin, protocatechaldehyde, indigo, isatin, curcumin, spinulosin, apigenidin and orcein. Extracts or decoctions containing these natural dyes and in particular henna-based poultices or extracts may also be used.

When they are present, the direct dye(s) more particularly represent from 0.001% to 10% by weight and preferably from 0.005% to 5% by weight relative to the total weight of the composition.

Among the acidifying agents that may be mentioned, by way of example, are mineral or organic acids, for instance hydrochloric acid, orthophosphoric acid or sulfuric acid, carboxylic acids, for instance acetic acid, tartaric acid, citric acid and lactic acid, and sulfonic acids.

Among the basifying agents, examples that may be mentioned include aqueous ammonia, alkaline carbonates, alkanolamines such as monoethanolamine, diethanolamine and triethanolamine, and also derivatives thereof, sodium hydroxide, potassium hydroxide and the compounds of formula (III) below: R_(a)R_(b)N—Z—NR_(c)R_(d); in which Z is a linear or branched (C₁-C₆)alkylene group, which is optionally substituted, especially with one or more hydroxyl or amino groups, and preferably Z=propylene optionally substituted with a hydroxyl group or a C₁-C₄ alkyl radical; R_(a), R_(b), R_(c) and R_(d), which may be identical or different, represent a hydrogen atom or a C₁-C₄ alkyl or C₁-C₄ hydroxyalkyl radical.

The cosmetic composition according to the invention may be present in various forms, such as in the form of liquids, creams, gels, or any other form that is suitable for dyeing keratin fibres, and especially human hair.

As indicated previously, the invention also relates to the use of the cosmetic composition as defined previously for dyeing keratin fibres, in particular human keratin fibres such as the hair.

III. Dyeing Process

The present invention also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, comprising the following steps:

-   -   either the application to said keratin fibres of a cosmetic         composition comprising one or more abovementioned compounds of         formula (I), said composition also optionally comprising one or         more chemical oxidizing agents as described above;     -   or the sequential application to said keratin fibres, in a first         step a), of a composition comprising one or more abovementioned         compounds of formula (I), and then, in a second step b), an         oxidizing composition, which comprises one or more chemical         oxidizing agents as described above;

it being understood that, between step a) and step b), said fibres may be rinsed, and/or washed and then optionally dried.

Preferably, said cosmetic composition is applied for a leave-on time of between 1 and 60 minutes, preferably between 5 and 40 minutes and even more preferentially between 10 and 30 minutes.

The cosmetic composition is generally applied to the keratin fibres at room temperature, preferably between 25 and 55° C.

According to one embodiment, the cosmetic composition according to the invention is applied to keratin fibres, especially human keratin fibres such as the hair, in the presence of one or more chemical oxidizing agents as described above, for a time that is sufficient to obtain the desired lightening.

According to a particular embodiment, the dyeing process according to the invention uses one or more chemical oxidizing agents, as described above, separately from the compound of formula (I) in another cosmetic composition. The two cosmetic compositions may be mixed just before use or may be used separately.

According to one variant, the dyeing process according to the invention consists in applying to keratin fibres, especially human keratin fibres such as the hair, a ready-to-use cosmetic composition which results from the mixing of a cosmetic composition comprising one or more compounds of abovementioned formula (I) and a cosmetic composition comprising one or more chemical oxidizing agents, as described previously. The ready-to-use cosmetic composition that is thus applied to the keratin fibres may be in various forms, such as in the form of liquids, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and in particular human hair.

Thus, the present invention also relates to a process for lightening keratin fibres, in particular human keratin fibres such as the hair, in which (i) the cosmetic composition comprising, in a suitable dyeing medium, one or more compounds of formula (I) as defined previously, free of chemical oxidizing agent, and (ii) a cosmetic composition comprising one or more chemical oxidizing agents as defined previously are applied to said fibres; compositions (i) and (ii) being applied to said keratin fibres sequentially or simultaneously for a time that is sufficient to obtain the desired lightening, and the fibres are then rinsed, optionally washed with shampoo, rinsed again, and the resulting fibres are dried or left to dry.

The oxidizing composition may also contain various adjuvants conventionally used in cosmetic compositions, in particular compositions for dyeing the hair and as defined previously.

For the purposes of the present invention, the term “sequentially” means that the oxidizing composition is applied before or after the cosmetic composition, i.e. as a pre-treatment or a post-treatment, preferably as a pre-treatment.

The pH of the oxidizing composition containing the chemical oxidizing agent is such that, after mixing with the cosmetic composition, the pH of the resulting composition applied to the keratin fibres preferably ranges between 2 and 12 approximately, even more preferentially between 3 and 10 and even more particularly between 4 and 9.5. It may be adjusted to the desired value by means of acidifying or basifying agents usually used in the dyeing of keratin fibres and as defined previously.

IV. Compounds of Leuco Type, Cosmetic Compositions Containing Same and Dyeing Process Using Same

The present invention also relates to compounds of leuco type of formula (II) below, organic or mineral acid or base salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof and/or solvates thereof:

in which formula (II) R₁ to R₁₀, n and n′ have the same meanings as those indicated previously in formula (I), and it being understood that:

-   -   the compound of formula (II) is dissymmetric,     -   the sum of n+n′ is greater than or equal to 1,     -   when the compound of formula (II) is cationic, it comprises one         or more An⁻ to ensure the electrical neutrality of the molecule,         and     -   when the compound of formula (II) is cationic and comprises a         sulfonate group, then M⁺ and An⁻ may be absent to ensure the         electrical neutrality of said molecule.

In particular, the preferred variants of n, n′ and R₁ to R₁₀, of the cationic heterocycles, of the non-cationic heterocycles and of the ammonium radicals in formula (II) of the compounds of leuco type correspond to those indicated in formula (I) of the direct dyes.

The compounds of leuco type corresponding to formula (II) are generally obtained by reacting the compounds of azomethine type of formula (I) with a reducing agent according to the reaction scheme below:

Synthetic approaches similar to this scheme are described in patent applications FR 2 056 799, FR 2 047 932, FR 2 165 965 and FR 2 262 023.

The compounds of leuco type of formula (II) are used as precursors of the direct dyes of formula (I).

Preferably, the compounds of leuco type of formula (II) are chosen from compounds (1) to (16′) corresponding to the reduced form of the azomethine direct dyes (1) to (16) as defined previously, the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates, and also mixtures thereof.

with An⁻ as defined previously.

Preferably, the direct dyes of formula (I) according to the present invention are of structure (1′), (2′), (3′), (4′), (5′) or (6′), and also the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates.

According to one embodiment, the compound of formula (II) does not represent the following compound:

According to the invention, the compounds of formula (II) may optionally be salified with mineral acids, for instance HCl, HBr, H₂SO₄ or H₃PO₄, or organic acids, for instance acetic acid, lactic acid, tartaric acid, citric acid, succinic acid, benzenesulfonic acid, para-toluenesulfonic acid, formic acid or methanesulfonic acid.

According to the invention, the compounds of formula (II) may optionally be in the form of solvates, for example a hydrate or a solvate of a linear or branched alcohol, for instance ethanol or isopropanol.

In particular, the invention relates to a cosmetic composition comprising one or more compounds of leuco type of formula (II) as defined previously.

Preferably, the cosmetic composition comprises one or more compounds of leuco type of formula (II) chosen from compounds (1′) to (16′) as defined previously, the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates, and also mixtures thereof.

Even more preferentially, the cosmetic composition comprises one or more azomethine direct dyes of formula (II) chosen from compounds (1), (2), (3), (4), (5) and (6) mentioned previously.

According to one variant of the invention, the cosmetic composition comprises one or more compounds of formulae (I) and (II) as defined above; preferably, the compounds of formula (I) and of formula (II) are chosen from compounds (1) to (16) and compounds (1′) to (16′), as described above.

According to another variant of the invention, the cosmetic composition is a ready-to-use cosmetic composition, especially for dyeing keratin fibres, in particular human keratin fibres such as the hair, which results from the mixing of a cosmetic composition comprising one or more compounds of the abovementioned formula (II) and of a cosmetic composition comprising one or more chemical oxidizing agents, as described previously.

According to one variant of the invention, the cosmetic composition does not comprise any chemical oxidizing agent. When the cosmetic composition does not comprise any chemical oxidizing agent, the dyeing of keratin fibres using the leuco compounds of formula (II) is performed with atmospheric oxygen. Simple exposure to air of the keratin fibres, especially human keratin fibres such as the hair, treated with the composition comprising the compound(s) of leuco type makes it possible to generate the colouring species and, consequently, to colour the fibres.

The cosmetic compositions according to these variants may also comprise one or more chemical oxidizing agents, chosen in particular from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, peracids, and oxidase enzymes (with the possible cofactors thereof), among which mention may be made of peroxidases, 2-electron oxidoreductases such as uricases, and 4-electron oxygenases, for instance laccases, and preferably, the chemical oxidizing agent is hydrogen peroxide.

The present invention also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, comprising the following steps:

-   -   either the application to said keratin fibres of a cosmetic         composition comprising one or more abovementioned compounds of         formula (II), said composition also optionally comprising one or         more chemical oxidizing agents as described above;     -   or the sequential application to said keratin fibres, in a first         step a), of a composition comprising one or more abovementioned         compounds of formula (II), and then, in a second step b), an         oxidizing composition, which comprises one or more chemical         oxidizing agents as described above;

it being understood that, between step a) and step b), said fibres may be rinsed, and/or washed and then optionally dried.

Preferably, said cosmetic composition is applied for a leave-on time of between 1 and 60 minutes, preferably between 5 and 40 minutes and even more preferentially between 10 and 30 minutes.

The cosmetic composition is generally applied to the keratin fibres at room temperature, preferably between 25 and 55° C.

According to a particular embodiment, the present invention also relates to a dyeing process, in one or more steps, in which a cosmetic composition comprising one or more abovementioned compounds of leuco type of formula (II) is applied to keratin fibres, especially human keratin fibres such as the hair, for a time that is sufficient to develop the desired colouring, optionally after which the fibres are optionally rinsed, optionally washed with shampoo, rinsed again, and the resulting fibres are dried or left to dry.

According to a particular embodiment of the invention, the process for dyeing keratin fibres, especially human keratin fibres such as the hair, does not use any chemical oxidizing agent. When the dyeing process does not use any chemical oxidizing agent, the dyeing operation using the leuco compounds of formula (II) is performed with atmospheric oxygen. Simple exposure to air of the keratin fibres, especially human keratin fibres such as the hair, treated with the composition comprising the compound(s) of leuco type makes it possible to generate the colouring species and, consequently, to colour the fibres.

According to one variant, the dyeing process is a dyeing process in which a cosmetic composition comprising one or more compounds of leuco type of the abovementioned formula (II) is applied to keratin fibres, especially human keratin fibres such as the hair, in the presence of one or more chemical oxidizing agents as described previously, for a time that is sufficient to develop the desired colouring, optionally after which the fibres are optionally rinsed, optionally washed with shampoo, rinsed again, and the resulting fibres are dried or left to dry.

According to another variant, the dyeing process is a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in which a ready-to-use cosmetic composition which results from the mixing of a cosmetic composition comprising one or more compounds of formula (II) as defined previously, and of a cosmetic composition comprising one or more chemical oxidizing agents, as described previously, is applied to said fibres. The ready-to-use cosmetic composition that is thus applied to the keratin fibres may be in various forms, such as in the form of liquids, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and in particular human hair.

According to one variant, the dyeing process is a sequential dyeing process which consists, in a first stage, in applying to wet or dry keratin fibres, especially human keratin fibres such as the hair, a cosmetic composition comprising one or more leuco compounds of formula (II) as defined previously, followed, in a second stage, by revealing the colour by applying an oxidizing composition containing one or more chemical oxidizing agents as defined previously. This process especially makes it possible to perform clean dyeing operations, i.e. dyeing operations that produce very little or no staining of linen and clothing, since the first composition uses compounds of formula (II) that are uncoloured or very sparingly coloured, and the colour is then revealed once said colourless compounds (II) have been applied to the hair, so that the staining of fabrics is avoided during the dyeing process.

According to an advantageous variant, the dyeing process consists in simultaneously applying to wet or dry keratin fibres, especially human keratin fibres such as the hair, a cosmetic composition comprising one or more leuco compounds of formula (II) as defined previously, and an oxidizing composition comprising one or more chemical oxidizing agents as defined previously.

According to another advantageous variant, the chemical oxidizing agent(s) may be applied simultaneously or sequentially to the cosmetic composition comprising the compounds of leuco type of formula (II).

The cosmetic composition comprising the chemical oxidizing agent(s) may be applied to the keratin fibres before, simultaneously with or after the cosmetic composition comprising the compounds of leuco type of formula (II) according to the invention.

According to another variant, the dyeing process consists in applying to keratin fibres, especially human keratin fibres such as the hair, a ready-to-use cosmetic composition which results from the mixing of a cosmetic composition comprising one or more compounds of leuco type of the abovementioned formula (II) and a cosmetic composition comprising one or more chemical oxidizing agents, as described previously. The ready-to-use cosmetic composition that is thus applied to the keratin fibres may be in various forms, such as in the form of liquids, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and in particular human hair.

The leave-on time for the composition(s) ranges from 1 to 60 minutes, preferably from 1 to 40 minutes and even more preferentially from 1 to 30 minutes.

The cosmetic composition comprising such compounds of leuco type is generally applied to the keratin fibres at room temperature, preferably between 25 and 55° C.

V. Dyeing Device

The present invention also relates to a multi-compartment device or “kit” comprising a first compartment containing one or more compounds of formulae (I) and/or (II), and a second compartment containing one or more chemical oxidizing agents as defined above.

In particular, the invention relates to a multi-compartment dyeing device or dyeing “kit” comprising a first compartment containing a cosmetic composition comprising one or more direct dyes of formula (I) as defined previously or containing one or more compounds of leuco type of formula (II) as defined previously, and a second compartment comprising one or more chemical oxidizing agents as defined previously.

More particularly, the invention relates to a multi-compartment dyeing device or dyeing kit comprising a first compartment containing a cosmetic composition comprising one or more dyes of formula (I) as defined previously, free of chemical oxidizing agent, and a second compartment containing a cosmetic composition comprising one or more chemical oxidizing agents.

According to a particular embodiment, the multi-compartment dyeing device or dyeing kit comprises a first compartment containing a cosmetic composition comprising one or more compounds of leuco type of the abovementioned formula (II), and a second compartment containing a cosmetic composition comprising one or more chemical oxidizing agents.

According to a particular embodiment, the device may comprise at least one compartment comprising a cosmetic composition comprising one or more compounds of leuco type of the abovementioned formula (II). In this case, the composition comprising the compound(s) of leuco type of formula (II) is applied to the keratin fibres, which become coloured due to their exposure to air.

The devices mentioned above are suitable for dyeing keratin fibres.

The invention also relates to the use of one or more compounds of formula (I) and/or (II), optionally in the presence of one or more chemical oxidizing agents as defined previously, for dyeing keratin fibres, in particular human keratin fibres such as the hair.

The examples below are given to illustrate the invention and do not in any way limit the scope thereof.

The compounds were fully characterized via standard spectroscopic or spectrometric methods known to those skilled in the art.

SYNTHESIS EXAMPLES Synthesis of 4-{4-amino-3-[4-aminophenylimino]-6-iminocyclohexa-1,4-dien-1-ylamino}phenol Hydrate (a)

i) Synthesis of N-(5-chloro-2,4-dinitrophenyl)benzene-1,4-diamine (1a)

8.44 mmol of 1,5-dichloro-2,4-dinitrobenzene (2.0 g, 1 equivalent) and 27.85 mmol of diisopropylethylamine (4.85 ml, 3.3 equivalents) are placed in a 250 ml three-necked flask under an inert atmosphere containing 40 ml of ethanol. 9.28 mmol of benzene-1,4-diamine dihydrochloride (1.68 g, 1.1 equivalents) are added portionwise while maintaining the temperature of the reaction medium below 25° C. with a bath constituted of an ice/water mixture, and the reaction is monitored by TLC with dichloromethane as eluent. After 1 hour at room temperature, the insoluble dark red matter formed is filtered off on a sinter, washed with 2×20 ml of ethanol, suction-filtered and dried in a desiccator (P₂O₅, vacuum, 40° C.) to give compound (1a) in the form of a dark red solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1a).

ii) Synthesis of 4-({5-[4-aminophenyl)amino]-2,4-dinitrophenyl}amino)phenol

6.47 mmol of compound (1a) (2.0 g, 1 equivalent), 6.80 mmol of 4-aminophenol (742 mg, 1.05 equivalents), 6.80 mmol of diisopropylethylamine (1.18 ml, 1.05 equivalents) and 15 ml of 1-methyl-2-pyrrolidinone are placed in a 100 ml three-necked flask under an inert atmosphere. The reaction medium is heated to 70° C. and the reaction is monitored by TLC with an eluent constituted of a dichloromethane/methanol mixture (95/5). After 1 hour at 70° C., the heating is stopped and the reaction medium is then poured onto ice. The insoluble brown matter formed is filtered off on a sinter, washed with 3×50 ml of water, suction-filtered and then dried in a desiccator (P₂O₅, vacuum, 40° C.) to give compound (2a) in the form of a dark brown solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (2a).

iii) Synthesis of 4-{4-amino-3-[4-aminophenylimino]-6-iminocyclohexa-1,4-dien-1-ylamino}phenol Hydrate (a)

5.24 mmol of compound (2a) (2.0 g) are dissolved in 500 ml of methanol and are then reduced by catalytic hydrogenation with 5% palladium on charcoal in the presence of hydrogen at 70° C. under a pressure of 50 bar using an H-Cube midi hydrogenator sold by the company Thales Nanotechnologies, with a flow rate of 5 ml/minute. The resulting solution is evaporated and the black solid obtained is then purified by chromatography on normal-phase silica with an eluent constituted of dichloromethane and methanol. Compound (a) is obtained in the form of a light brown solid.

Synthesis of 2-[{4-[2-amino-4-imino-5-phenylaminocyclohexa-2,5-dienylideneamino]phenyl}-(2-hydroxyethyl)amino]ethanol (b)

i) Synthesis of 2,2′-({4-[(5-chloro-2,4-dinitrophenyl)amino]phenyl}imino)diethanol (1b)

63.29 mmol of 1,5-dichloro-2,4-dinitrobenzene (15.0 g, 1 equivalent) and 202.52 mmol of diisopropylethylamine (35.3 ml, 3.2 equivalents) are placed in a 500 ml three-necked flask under an inert atmosphere containing 150 ml of ethanol. 66.45 mmol of 2,2′-[(4-aminophenyl)imino]diethanol sulfate hydrate (salt) (20.75 g, 1.05 equivalents) are added portionwise while maintaining the temperature of the reaction medium below 25° C. with a bath constituted of an ice/water mixture, and the reaction is monitored by TLC with dichloromethane as eluent. After 2 hours at room temperature, the insoluble dark brown matter formed is filtered off on a sinter, washed with 2×250 ml of water, suction-filtered and dried in a desiccator (P₂O₅, vacuum, 40° C.) to give compound (1b) in the form of a dark brown solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1 b).

ii) Synthesis of 2,2′-[(4-({[2,4-dinitro-5-(phenylamino)phenyl]amino}phenyl)imino]diethanol (2b)

12.60 mmol of compound (1 b) (5.0 g, 1 equivalent), 12.60 mmol of aniline (1.15 ml, 1 equivalent), 13.86 mmol of diisopropylethylamine (2.41 ml, 1.1 equivalents) and 20 ml of 1-methyl-2-pyrrolidinone are placed in a 250 ml three-necked flask under an inert atmosphere. The reaction medium is heated to 100° C. and the reaction is monitored by HPLC. After 6 hours at 100° C., the heating is stopped and the reaction medium is then poured onto ice. The insoluble brown matter formed is filtered off on a sinter, washed with 3×200 ml of water, suction-filtered and then dried in a desiccator (P₂O₅, vacuum, 40° C.) to give compound (2b) in the form of a dark brown solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (2b).

iii) Synthesis of 2-[{4-[2-amino-4-imino-5-phenylaminocyclohexa-2,5-dienylideneamino]phenyl}-(2-hydroxyethyl)amino]ethanol (b)

12.13 mmol of compound (2b) (5.5 g, 1 equivalent) and 2.7 g of 5% palladium on charcoal are placed in a 250 ml three-necked flask under an inert atmosphere containing 60 ml of methanol. The reaction medium is heated to 65° C., 121.29 mmol of ammonium formate (7.65 g, 10 equivalents) are then added portionwise to the reaction medium and the reaction is monitored by TLC (dichloromethane/methanol: 95/5). After 2 hours at 65° C., the reaction medium is filtered through a sinter packed with Celite and the filtrate is then evaporated. The black solid obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol. Compound (b) is obtained in the form of a black solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (b).

Synthesis of 2-[{4-[2-amino-5-(4-ethoxyphenylamino)-4-iminocyclohexa-2,5-dienylideneamino]phenyl}(2-hydroxyethyl)amino]ethanol (c)

i) Synthesis of 2,2′-{[4-({5-[(4-ethoxyphenyl)amino]-2,4-dinitrophenyl}amino)phenyl]imino}diethanol (1c)

12.60 mmol of compound (1b) (5.0 g, 1 equivalent), 12.60 mmol of 4-ethoxyaniline (1.63 ml, 1 equivalent), 13.86 mmol of diisopropylethylamine (2.41 ml, 1.1 equivalents) and 20 ml of 1-methyl-2-pyrrolidinone are placed in a 250 ml three-necked flask under an inert atmosphere. The reaction medium is heated to 100° C. and the reaction is monitored by HPLC. After 3 hours at 100° C., the heating is stopped and the reaction medium is then poured onto ice. The insoluble dark red matter formed is filtered off on a sinter, washed with 3×200 ml of water, suction-filtered and then dried in a desiccator (P₂O₅, vacuum, 40° C.) to give compound (1c) in the form of a dark brown solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1c).

ii) Synthesis of 2-[{4-[2-amino-5-(4-ethoxyphenylamino)-4-iminocyclohexa-2,5-dienylideneamino]phenyl}(2-hydroxyethyl)amino]ethanol (c)

12.46 mmol of compound (1c) (6.2 g, 1 equivalent) and 3.0 g of 5% palladium on charcoal are placed in a 250 ml three-necked flask under an inert atmosphere containing 65 ml of methanol. The reaction medium is heated to 65° C., 124.62 mmol of ammonium formate (7.86 g, 10 equivalents) are then added portionwise to the reaction medium and the reaction is monitored by TLC (dichloromethane/methanol: 95/5). After 2 hours at 65° C., the reaction medium is filtered through a sinter packed with Celite and the filtrate is then evaporated. The black solid obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol. Compound (c) is obtained in the form of a black solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (c).

Synthesis of 3-(4-amino-3-{4-[bis(2-hydroxyethyl)amino]phenylimino}-6-iminocyclohexa-1,4-dienylamino)phenol (d)

i) Synthesis of 3-{[5-({4-bis(2-hydroxyethyl)amino]phenyl}amino)-2,4-dinitrophenyl]amino}phenol (1d)

7.62 mmol of compound (1b) (3.0 g, 1 equivalent), 7.62 mmol of 3-aminophenol (832 mg, 1 equivalent), 8.38 mmol of diisopropylethylamine (1.46 ml, 1.1 equivalents) and 20 ml of 1-methyl-2-pyrrolidinone are placed in a 250 ml three-necked flask under an inert atmosphere. The reaction medium is heated to 100° C. and the reaction is monitored by TLC with an eluent constituted of a dichloromethane/methanol mixture (95/5). After 3 hours at 100° C., the heating is stopped and the reaction medium is then poured onto ice. The insoluble dark red matter formed is filtered off on a sinter, washed with 3×200 ml of water, suction-filtered and then dried in a desiccator (P₂O₅, vacuum, 40° C.) to give compound (1d) in the form of a dark red solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1d).

ii) Synthesis of 3-(4-amino-3-{4-[bis(2-hydroxyethyl)amino]phenylimino}-6-iminocyclohexa-1,4-dienylamino)phenol (d)

7.45 mmol of compound (1d) (3.5 g, 1 equivalent) and 1.70 g of 5% palladium on charcoal are placed in a 250 ml three-necked flask under an inert atmosphere containing 40 ml of methanol. The reaction medium is heated to 65° C., 74.55 mmol of ammonium formate (4.70 g, 10 equivalents) are then added portionwise to the reaction medium and the reaction is monitored by TLC (dichloromethane/methanol: 95/5). After 2 hours at 65° C., the reaction medium is filtered through a sinter packed with Celite and the filtrate is then evaporated. The black solid obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol. Compound (d) is obtained in the form of a black solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (d).

Synthesis of 4-(4-amino-3-{4-[bis(2-hydroxyethyl)amino]phenylimino}-6-iminocyclohexa-1,4-dienylamino)phenol (e)

i) Synthesis of 4-{[5-({4-[bis(2-hydroxyethyl)amino]phenyl}amino)-2,4-dinitrophenyl]amino}phenol (1e)

12.69 mmol of compound (1b) (5.0 g, 1 equivalent), 12.69 mmol of 4-aminophenol (1.39 g, 1 equivalent), 13.97 mmol of diisopropylethylamine (2.43 ml, 1.1 equivalents) and 20 ml of 1-methyl-2-pyrrolidinone are placed in a 100 ml three-necked flask under an inert atmosphere. The medium is heated to 100° C. and the reaction is monitored by TLC with an eluent constituted of a dichloromethane/methanol mixture (95/5). After 3 hours at 100° C., the heating is stopped and the reaction medium is then poured onto ice. The insoluble dark red matter formed is filtered off on a sinter, washed with 3×200 ml of water, suction-filtered and then dried in a desiccator (P₂O₅, vacuum, 40° C.) to give compound (1e) in the form of a dark red solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1e).

ii) Synthesis of 4-(4-amino-3-{4-[bis(2-hydroxyethyl)amino]phenylimino}-6-iminocyclohexa-1,4-dienylamino)phenol (e)

11.71 mmol of compound (1b) (5.5 g, 1 equivalent) and 2.25 g of 5% palladium on charcoal are placed in a 250 ml three-necked flask under an inert atmosphere containing 60 ml of methanol. The reaction medium is heated to 65° C., 117.15 mmol of ammonium formate (7.39 g, 10 equivalents) are then added portionwise to the reaction medium and the reaction is monitored by TLC (dichloromethane/methanol: 95/5). After 2 hours at 65° C., the reaction medium is filtered through a sinter packed with Celite and the filtrate is then evaporated. The black solid obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol. Compound (e) is obtained in the form of a black solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (e).

Examples of Dyeing Evaluation:

Cosmetic compositions 1 to 6 below were prepared:

Composition Composition Composition Composition Composition 1 2 3 4 5 Compound 500 mg (a) Compound 500 mg (b) Compound 500 mg (c) Compound 500 mg (d) Compound 500 mg (e) Water 79.5 g 79.5 g 79.5 g 79.5 g 79.5 g Ethanol 15 g 15 g 15 g 15 g 15 g Benzyl 5 g 5 g 5 g 5 g 5 g alcohol

2.0 g of compositions 1 to 6 are applied to a lock of 1.0 g of grey hair containing 90% white hairs. After a leave-on time of 30 minutes at room temperature, the lock is rinsed, washed with a standard shampoo and then dried.

Spectrocolorimetric Evaluation:

The colour of the locks was evaluated in the CIE L* a* b* system using a Minolta Spectrophotometer CM3610D colorimeter. In this L* a* b* system, the three parameters respectively denote the intensity of the colour (L*), the green/red colour axis (a*) and the blue/yellow colour axis (b*).

Colour Build-Up:

The variation in colouration between the non-dyed and dyed locks of hair is defined by (ΔE*) according to the following equation: ΔE*=√{square root over ((L*−L _(o)*)²+(a*−a _(o)*)²+(b*−b _(o)*)²)}

In this equation, L*, a* and b* represent the values measured on locks of hair after dyeing and L₀*, a₀* and b₀* represent the values measured on locks of hair before dyeing. The higher the value of ΔE*, the greater the colour build-up.

Results:

The colours obtained on the lock thus treated are collated in the attached table:

Composition 1 Composition 2 Composition 3 Composition 4 Composition 5 L* = 28.79 L* = 24.22  L* = 23.41  L* = 23.52 L* = 22.68  a* = 3   a* = −4.74 a* = −1.22   a* = −4.01  a* = −1.1   b* = 4.69  b* = −0.97 b* = −0.34   b* = −0.89  b* = −0.1  ΔE* = 35.13  ΔE* = 41.32   ΔE* = 41.63   ΔE* = 41.88  ΔE* = 42.24   Brown Dark green Blueish-black Dark green Blueish-black

It is seen through these results that the compositions according to the invention give intense, chromatic hair colourings and good colour build-up.

COMPARATIVE EXAMPLES

The following dye compositions A, B (comparative) and C (invention) were prepared from the ingredients mentioned in the table below. The contents are expressed as percentages of active material (in g) relative to the total weight of the composition.

Compound 1

Compound 2

Compound 3 Composition Composition A Composition B C (comparative) (comparative) (invention) Compound 1 0.5 — — Compound 2 — 0.5 — Compound 3 — 0.5 Pure ethyl alcohol 15 15 15 Benzyl alcohol 5 5 5 Water 79.5 79.5 79.5

Process

2 g of each of the compositions are applied to 1 g locks of natural Caucasian hair containing 90% white hairs. After 30 minutes, the locks are rinsed, shampooed and then dried. The colorimetric data of each of the locks are then measured with a Minolta CM-3610d spectrophotometer.

Results

The results are given in the table below.

L* a* b* ΔE colour Composition A 50.24 2.94 16.52 9.66 Very very (comparative) light brown Composition B 47.34 1.58 12.22 13.15 Very very (comparative) light grey Composition C 28.79 3.00 4.69 35.13 Brown (invention)

It is seen from the above table that the colour obtained with the comparative compositions A and B is significantly lighter than that obtained with composition C according to the invention. It should also be noted that the colour build-up is significantly greater for the composition according to the invention than for that obtained with the comparative compositions. Finally, it was not possible to obtain a brown shade with the comparative compositions A and B, whereas composition C according to the invention makes it possible to obtain a very intense grey-black colour. 

The invention claimed is:
 1. A compound chosen from compounds of formulae (I) and/or (II) below, organic or mineral acid or base salts thereof, tautomeric forms thereof, optical isomers thereof, geometrical isomers thereof, or solvates thereof:

wherein formulae (I) and (II): n and n′, which may be identical or different, represent an integer equal to 0, 1, 2, 3, 4 or 5; R₁ and R₂, which may be identical or different, represent: a halogen atom; a sulfonic radical —SO₃H or sulfonate radical —SO₃ ⁻; a carboxyl radical —CO₂H, a carboxylate radical —COO⁻; an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl; an aromatic or non-aromatic, 5- to 6-membered non-cationic heterocycle, substituted with: an ammonium radical —N⁺RR′R″, An⁻ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl; an ammonium radical —N⁺RR′R″, An⁻, with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group; amino; hydroxyl, or thiol; a radical —W—R₇, in which: W represents: an oxygen or sulfur atom, a divalent group —N(R₈)— or a linear or branched, saturated or unsaturated, divalent hydrocarbon-based chain, comprising from 1 to 14 carbon atoms, the hydrocarbon-based chain being:  optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium —N⁺RR′R″ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, or b), aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl; and/or  optionally interrupted, optionally starting and/or optionally terminating with one or more divalent heteroatoms or groups, which may be identical or different, chosen from:  —O—, —S—, —N(R₁₀)—, —S(O)—, —S(O)₂—, and —C(X)— with X representing an oxygen or sulfur atom or a group NR₁₀ wherein R₁₀ represents a hydrogen atom or a (C₁-C₆)alkyl group, or  combinations thereof; R₇ and R₈, which may be identical or different, represent: a hydrogen atom, a linear or branched C₁-C₁₄ alkyl group, said alkyl group being:  optionally interrupted with at least one heteroatom or group, which may be identical or different, chosen from —O—, —S—, —N(R₈)—, —S(O)—, —S(O)₂—, or —C(X)— with X representing an oxygen or sulfur atom or a group NR₁₀ wherein R₁₀ represents a hydrogen atom or a (C₁-C₆)alkyl group, or combinations thereof; and/or  optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, optionally substituted with one or more (C₁-C₄)alkyl groups, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium —N⁺RR′R″ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, or b), aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl; R₃ and R₄, which may be identical or different, representing: a hydrogen atom, a (C₁-C₆)alkyl radical optionally substituted with at least one radical chosen from i) hydroxyl, ii) (C₁-C₄)alkoxy, iii) amino, iv) (C₁-C₆)alkylamino, or v) di(C₁-C₆)alkylamino; R₅ and R₆, which may be identical or different, represent an atom or group chosen from: a hydrogen atom, a halogen atom, a C₁-C₆ alkyl radical, a (C₁-C₆)alkyl radical substituted with at least one radical chosen from the following radicals: i) hydroxyl, ii) amino —NH₂, iii) (C₁-C₆)alkylamino, or iv) di(C₁-C₆)alkylamino, a (C₁-C₆)alkoxy radical, or a (C₁-C₆)alkoxy radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino, iii) (C₁-C₆)alkylamino, or iv) di(C₁-C₆)alkylamino, it being understood that: the compounds of formulae (I) and (II) are dissymmetric, the sum of n+n′ is greater than or equal to 1, when the compound of formula (I) or (II) is cationic, it optionally comprises one or more anions An⁻ and optionally one or more cations M⁺ to ensure the electrical neutrality of the molecule; with: An⁻ denoting an anion chosen from bromide, chloride, methylsulfate, toluenesulfonate ions, or a mixture of these ions; and M⁺ representing a cation chosen from sodium, potassium, magnesium, calcium, or ammonium.
 2. The compound of formulae (I) or (II) according to claim 1, wherein R₃ and R₄ represent a hydrogen atom.
 3. The compound of formulae (I) or (II) according to claim 1, wherein R₅ and R₆ represent a hydrogen atom.
 4. The compound of formulae (I) or (II) according to claim 1, wherein n represents an integer equal to 0 or
 1. 5. The compound of formulae (I) or (II) according to claim 1, wherein R₁ and R₂, which may be identical or different, represent: a sulfonic radical —SO₃H or sulfonate radical —SO₃ ⁻; a radical —W—R′₇, in which: W′ represents an oxygen or sulfur atom or a divalent group —N(R′₈)—; R′₇ and R′₈, which may be identical or different, represent a linear or branched, saturated or unsaturated, alkyl group, comprising from 1 to 8 carbon atoms, said hydrocarbon-based chain being: optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with a radical chosen from the following radicals: a) ammonium —N⁺RR′R″, An⁻ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, and b) aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more radicals, which may be identical or different, chosen from C₁-C₄ alkyl; and/or optionally interrupted with at least one divalent heteroatom or group, which may be identical or different, chosen from: —O—, —N(R₁₀)—, and —C(O)—, with R₁₀, or combinations thereof; R′₇, and R′₈, which may be identical or different, represent: a hydrogen atom, a linear or branched C₁-C₁₄ alkyl group, said alkyl group being: optionally interrupted with at least one heteroatom or group, which may be identical or different, chosen from —O—, —S—, —N(R₁₀)—, —S(O)—, —S(O)₂—, —C(X)—, or combinations thereof; and/or optionally substituted with at least one radical, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with a radical chosen from the following radicals: a) ammonium —N⁺RR′R″, or b), aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl; n and n′ represent an integer equal to 0 or 1; R₃ and R₄, which may be identical or different, represent a hydrogen atom, a (C₁-C₆)alkyl radical, or a (C₁-C₆)alkyl radical substituted with one or more radicals chosen from hydroxyl or C₁-C₄ alkoxy; R₅ and R₆ represent a hydrogen atom; An⁻ is an anionic counterion chosen from bromide, chloride, methyl sulfate, toluenesulfonate ions, or a mixture of these ions.
 6. The compound of formulae (I) or (II) according to claim 1, wherein R₁ and R₂, which may be identical or different, represent a group —WR₇ in which: W represents an oxygen atom or a divalent group —N(R₈)—; R₇ and R₈ are chosen from: a hydrogen atom, or a C₁-C₈ alkyl group; optionally interrupted with at least one heteroatom or group, which may be identical or different, chosen from —O—, —S—, —S(O)—, S(O)₂, and —C(X)— with X representing an oxygen or sulfur atom or N—R₁₀, or combinations thereof; and/or optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C₁-C₄ alkoxy, iii) amino, iv) C₁-C₄ mono- and/or dialkylamino, v) ammoniums —N⁺RR′R″, vi) optionally substituted 5- to 10-membered cationic heteroaryls or heterocycles, optionally substituted with one or more (C₁-C₄)alkyl groups chosen from imidazoliums, piperaziniums, pyrrolidiniums, morpholiniums, or piperidiniums, and vii) 5- or 6-membered non-cationic heteroaryls or heterocycles, optionally substituted with a radical chosen from ammoniums —N⁺RR′R″ with R, R′ and R″ as defined previously, and 5- to 10-membered cationic heteroaryls.
 7. The compound of formulae (I) or (II) according to claim 1, wherein R₁ and R₂, which may be identical or different, represent a group chosen from: a radical —OR₇; a radical —SR₇; a radical —NR₇R₈; a linear or branched C₁-C₁₄ alkyl radical, the alkyl radical being: optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from —O—, —S—, —N(H)—, —N(R₁₀)— —S(O)—, S(O)₂, —C(X)— with X representing an oxygen or sulfur atom or N—R₁₀, or combinations thereof; and/or optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C₁-C₄ alkoxy, iii) amino —NH₂, iv) C₁-C₆ mono- and/or dialkylamino, v) ammoniums —N⁺RR′R″ with R, R′ and R″, and vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, optionally substituted with one or more (C₁-C₄)alkyl groups, vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with a radical chosen from the following radicals: ammoniums —N⁺RR′R″, or optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more (C₁-C₄)alkyl groups; a hydroxyl, amino, C₁-C₄ alkylamino, C₁-C₄ dialkylamino, C₁-C₄ alkoxy, C₁-C₄ alkyl, or C₁-C₄ hydroxyalkyl radical; a linear or branched C₁-C₁₄ alkoxy radical, said alkoxy radical being: optionally interrupted with at least one heteroatom or group, which may be identical or different, chosen from —O—, —S—, —S(O)—, S(O)₂, —C(X)— with X representing an oxygen or sulfur atom or N—R, or combinations thereof; and/or optionally substituted with at least one radical, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C₁-C₄ alkoxy, iii) amino —NH₂, iv) C₁-C₆ mono- and/or dialkylamino, v) ammoniums —N⁺RR′R″, and vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, optionally substituted with one or more (C₁-C₄)alkyl groups vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with a radical chosen from the following radicals: ammoniums —N⁺RR′R″, and/or optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more (C₁-C₄)alkyl groups; a hydroxyl, amino, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 alkoxy, C1-C4 alkyl, or C1-C4 hydroxyalkyl radical.
 8. The compound of formulae (I) or (II) according to claim 1, wherein n and n′ represent an integer equal to 1, and R₁ and R₂ are, respectively, in position 4 and 4′.
 9. The compound of formulae (I) or (II) according to claim 1, wherein n represents an integer equal to 1, n′ represents an integer equal to 0, and R1 is in position
 4. 10. The compound of formulae (I) or (II) according to claim 1, wherein said cationic heterocycle(s) are chosen from imidazoliums, piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums; optionally substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(C₁-C₄)alkyl radicals.
 11. The compound of formulae (I) or (II) according to claim 1, wherein said non-cationic heterocycle(s) are 5- or 6-membered and are chosen from piperidines, piperazines, pyrrolidines, morpholines, thiazoles, imidazoles, or pyridines, the 5- or 6-membered non-cationic heterocycles optionally substituted with: an ammonium radical —N⁺RR′R″, An⁻ with R, R′ and R″, which may be identical or different, representing a (C1-C4)alkyl group optionally substituted with one or more hydroxyl groups, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted with one or more identical or different radicals chosen from (hydroxy)(C₁-C₄)alkyl radicals.
 12. The compound of formulae (I) or (II) according to claim 1, wherein the non-cationic heterocycle(s) are pyrrolidines substituted with: an ammonium radical —N⁺RR′R″, An⁻, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted with one or more (hydroxy)(C₁-C₄)alkyl groups.
 13. The compound of formulae (I) or (II) according to claim 1, wherein R₁ and R₂, which may be identical or different, represent a group chosen from: hydroxyl, amino, (di)(hydroxy)(C₁-C₆)alkylamino, (hydroxy)(C₁-C₆)alkoxy, or (di)(alkoxy)alkylamino.
 14. The compound of formulae (I) or (II) according to claim 1, wherein the compound is chosen from compounds (1) to (16) and (1′) to (16′), geometrical or optical isomers thereof, tautomers thereof, organic or mineral acid or base salts thereof, or solvates thereof:

with An⁻ as defined in claim 1,


15. The compound of formulae (I) or (II) according to claim 1, wherein the compound of formula (II) cannot represent the following compound:


16. A cosmetic composition comprising at least one compound of formulae (I) and (II) according to claim
 1. 17. The composition according to claim 16, wherein the composition does not comprise any chemical oxidizing agent.
 18. The composition according to claim 16, wherein the composition further comprises at least one chemical oxidizing agent chosen from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts, perborates, persulfates, peracids, or oxidase enzymes.
 19. A method for dyeing keratin fibers, comprising: applying to the keratin fibers of a composition comprising at least one compound chosen from compounds of formulae (I) or (II) below, organic or mineral acid or base salts thereof, tautomeric forms thereof, optical isomers thereof, geometrical isomers thereof, or solvates thereof:

wherein formulae (I) and (II): n and n′, which may be identical or different, represent an integer equal to 0, 1, 2, 3, 4 or 5; R₁ and R₂, which may be identical or different, represent: a halogen atom; a sulfonic radical —SO₃H or sulfonate radical —SO₃; a carboxyl radical —CO₂H, a carboxylate radical —COO⁻; an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, with one or more identical or different radicals chosen from C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl; an aromatic or non-aromatic, 5- to 6-membered non-cationic heterocycle, substituted with: an ammonium radical —N⁺RR′R″, An⁻ with R, R′ and R″, which may be identical or different, representing a (C1-C4)alkyl group optionally substituted with at least one hydroxyl group, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, with one or more identical or different radicals chosen from C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl; an ammonium radical —N⁺RR′R″, An⁻; amino; hydroxyl, or thiol; a radical —W—R₇, in which: W represents: an oxygen or sulfur atom, a divalent group —N(R₈)— or a linear or branched, saturated or unsaturated, divalent hydrocarbon-based chain, comprising from 1 to 14 carbon atoms, the hydrocarbon-based chain being:  optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium —N⁺RR′R″, or b), aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl;  and/or  optionally interrupted, optionally starting and/or optionally terminating with one or more divalent heteroatoms or groups, which may be identical or different, chosen from:  —O—, —S—, —N(R₁₀)—, —S(O)—, —S(O)₂—, and —C(X)— with X representing an oxygen or sulfur atom or a group NR₁₀ wherein R₁₀ represents a hydrogen atom or a (C₁-C₆)alkyl group, or  combinations thereof; R₇ and R₈, which may be identical or different, represent: a hydrogen atom, a linear or branched C₁-C₁₄ alkyl group, said alkyl group being: optionally interrupted with at least one heteroatom or group, which may be identical or different, chosen from —O—, —S—, —N(R₈)—, —S(O)—, —S(O)₂—, or —C(X)— with X as defined previously, or combinations thereof; and/or optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, optionally substituted with one or more (C₁-C₄)alkyl groups, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium —N⁺RR′R″, or b), aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl; R₃ and R₄, which may be identical or different, representing: a hydrogen atom, a (C₁-C₆)alkyl radical optionally substituted with at least one radical chosen from i) hydroxyl, ii) (C₁-C₄)alkoxy, iii) amino, iv) (C₁-C₆)alkylamino, or v) di(C₁-C₆)alkylamino; R₅ and R₆, which may be identical or different, represent an atom or group chosen from: a hydrogen atom, a halogen atom, a C₁-C₆ alkyl radical, a (C₁-C₆)alkyl radical substituted with at least one radical chosen from the following radicals: i) hydroxyl, ii) amino —NH₂, iii) (C₁-C₆)alkylamino, or iv) di(C₁-C₆)alkylamino, a (C₁-C₆)alkoxy radical, or a (C₁-C₆)alkoxy radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino, iii) (C₁-C₆)alkylamino, or iv) di(C₁-C₆)alkylamino, it being understood that: the compounds of formulae (I) and (II) are dissymmetric, the sum of n+n′ is greater than or equal to 1, when the compound of formula (I) or (II) is cationic, it optionally comprises one or more anions An⁻ and optionally one or more cations M⁺ to ensure the electrical neutrality of the molecule; with: An⁻ denoting an anion chosen from bromide, chloride, methylsulfate, toluenesulfonate ions, or a mixture of these ions; M⁺ representing a cation chosen from sodium, potassium, magnesium, calcium, or ammonium; applying to the keratin fibers, in a first step a) a composition comprising at least one compound of formula (II), and then, in a second step b) applying an oxidizing composition comprising a chemical oxidizing agent chosen from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts, perborates, persulfates, peracids, or oxidase enzymes; wherein between step a) and step b), the fibers are optionally rinsed, and/or washed and then optionally dried.
 20. The method according to claim 19, wherein the composition comprising at least one compound chosen from compounds of formulae (I) or (II) is applied to the fibers, and the fibers are then optionally rinsed, and/or washed, and the fibers are dried or left to dry.
 21. The method according to claim 19, wherein the cosmetic composition comprising at least one compound of formula (II) is applied to the fibers, and the fibers are then optionally rinsed, and/or washed, and said fibers are dried or left to dry.
 22. A method of preparing a compound of formulae (I) or (II) as defined in claim 15, according to the following scheme: access to the compounds (I):

access to the compounds (IL

which comprises the compounds (I): a) in a first stage, in reacting one molar equivalent of 1,5-dinitrobenzene compound (i) comprising in positions 2 and 4 a nucleofugal group Nu with one molar equivalent of aniline compound (ii); Nu representing a nucleofugal group; wherein this reaction is performed i) in a polar protic solvent chosen from water or a mixture of water/C₁-C₁₀ alcohol ii) and/or in the presence of one or more mineral or organic basifying agents chosen from diisopropylethylamine, trimethylamine, sodium hydroxide, potassium hydroxide, a mineral carbonate, or an acetate, iii) and/or at a temperature of between 0° C. and 75° C.; and then b) in a second stage, in maintaining the reaction medium under stirring for a time of between 5 minutes and 48 hours; and then c) the reaction product (iii) is optionally purified via recrystallization, filtration, or chromatography; d) in a third stage, in reacting compound (iii) with one molar equivalent of aniline compound (iv); wherein this reaction is performed i) in a polar protic solvent chosen from water, a mixture of water/C₁-C₁₀ alcohol, 1-methyl-2-pyrrolidinone, acetone, acetonitrile, pyridine, or N,N-dimethylformamide; ii) and/or in the presence of one or more mineral or organic basifying agents, chosen from diisopropylethylamine, trimethylamine, sodium hydroxide, potassium hydroxide, a mineral carbonate, or an acetate, iii) and/or at a temperature of between room temperature and the reflux temperature the solvent; and then e) in a fourth stage, in maintaining the reaction medium under stirring for a time of between 5 minutes and 48 hours; and then f) the reaction product (v) is optionally purified via recrystallization, filtration, or chromatography; g) according to another variant, compound (iii) is not purified, and reacts with one molar equivalent of aniline compound (iv) under the same conditions as steps d) and e), to give the product (v), which is optionally purified via recrystallization, filtration, or chromatography; h) in a fifth stage, in performing a reduction reaction on compound (v), wherein the reaction is performed in a solvent chosen from esters, (C₁-C₆)alkyl acetates, ethyl acetate, (C₁-C₆)alkanols I, or mixtures thereof; to give compound (I′); and then i) compound (I′) optionally being N-substituted with halogenated reagents R₃-Hal and R₄-Hal, wherein Hal is a halogen atom, after filtration, removal of the precipitate and optionally purification by chromatography or recrystallization; j) said process comprising the compounds (II) in performing a reduction reaction on the compounds (I).
 23. A multi-compartment device comprising: (1) a first compartment comprising at least one compound chosen from compounds of formulae (I) and/or (II) below, organic or mineral acid or base salts thereof, tautomeric forms thereof, optical isomers thereof, geometrical isomers thereof, or solvates thereof:

in which formulae (I) and (II): n and n′, which may be identical or different, represent an integer equal to 0, 1, 2, 3, 4 or 5; R₁ and R₂, which may be identical or different, represent: a halogen atom; a sulfonic radical —SO₃H or sulfonate radical —SO₃ ⁻; a carboxyl radical —CO₂H, a carboxylate radical —COO⁻; an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, with one or more identical or different radicals chosen from C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl; an aromatic or non-aromatic, 5- to 6-membered non-cationic heterocycle, substituted with: an ammonium radical —N⁺RR′R″, An⁻ with R, R′ and R″, which may be identical or different, representing a (C₁-C₄)alkyl group optionally substituted with at least one hydroxyl group, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, with one or more identical or different radicals chosen from C₁-C₄ alkyl and C₁-C₄ hydroxyalkyl; an ammonium radical —N⁺RR′R″, An⁻; amino; hydroxyl, or thiol; a radical —W—R₇, in which: W represents: an oxygen or sulfur atom, a divalent group —N(R₈)— or a linear or branched, saturated or unsaturated, divalent hydrocarbon-based chain, comprising from 1 to 14 carbon atoms, the hydrocarbon-based chain being:  optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium —N⁺RR′R″, or b), aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl;  and/or  optionally interrupted, optionally starting and/or optionally terminating with one or more divalent heteroatoms or groups, which may be identical or different, chosen from:  —O—, —S—, —N(R₁₀)—, —S(O)—, —S(O)₂—, and —C(X)— with X representing an oxygen or sulfur atom or a group NR₁₀ wherein R₁₀ represents a hydrogen atom or a (C₁-C₆)alkyl group, or  combinations thereof; R₇ and R₈, which may be identical or different, represent: a hydrogen atom, a linear or branched C₁-C₁₄ alkyl group, said alkyl group being:  optionally interrupted with at least one heteroatom or group, which may be identical or different, chosen from —O—, —S—, —N(R₈)—, —S(O)—, —S(O)₂—, or —C(X)—, or combinations thereof; and/or  optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) (di)(C₁-C₆)(alkyl)amino, iii) ammoniums —N⁺RR′R″, iv) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, optionally substituted with one or more (C₁-C₄)alkyl groups, v) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium —N⁺RR′R″, or b), aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted with one or more identical or different radicals chosen from C₁-C₄ alkyl; R₃ and R₄, which may be identical or different, representing: a hydrogen atom, a (C₁-C₆)alkyl radical optionally substituted with at least one radical chosen from i) hydroxyl, ii) (C₁-C₄)alkoxy, iii) amino, iv) (C₁-C₆)alkylamino, or v) di(C₁-C₆)alkylamino; R₅ and R₆, which may be identical or different, represent an atom or group chosen from: a hydrogen atom, a halogen atom, a C₁-C₆ alkyl radical, a (C₁-C₆)alkyl radical substituted with at least one radical chosen from the following radicals: i) hydroxyl, ii) amino —NH₂, iii) (C₁-C₆)alkylamino, or iv) di(C₁-C₆)alkylamino, a (C₁-C₆)alkoxy radical, or a (C₁-C₆)alkoxy radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino, iii) (C₁-C₆)alkylamino, or iv) di(C₁-C₆)alkylamino, it being understood that: the compounds of formulae (I) and (II) are dissymmetric, the sum of n+n′ is greater than or equal to 1, when the compound of formula (I) or (II) is cationic, it optionally comprises one or more anions An⁻ and optionally one or more cations M⁺ to ensure the electrical neutrality of the molecule; with: An⁻ denoting an anion chosen from bromide, chloride, methylsulfate, toluenesulfonate ions, or a mixture of these ions; M⁺ representing a cation chosen from sodium, potassium, magnesium, calcium, or ammonium; and (2) a second compartment comprising at least one chemical oxidizing agent chosen from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts, perborates, persulfates, peracids, or oxidase enzymes. 